J Appl Biomed 7:137-142, 2009 | DOI: 10.32725/jab.2009.015

Effect of desmopressin on hemochromocytometric and clotting parameters in healthy blood donor dogs

Elisabetta Giudice¹, Claudia Giannetto², Stefania Casella², Giuseppe Arcuri², Giuseppe Piccione^2,*

¹ Department of Veterinary Public Health, Faculty of Veterinary Medicine, University of Messina, Italy

² Department of Experimental Sciences and Applied Biotechnology, Faculty of Veterinary Medicine, University of Messina, Italy

Six clinically healthy blood donor dogs were used to evaluate the effect of desmopressin (DDAVP) on haemochromocytometric and clotting parameters,. They received subcutaneously a physiological solution (placebo) and DDAVP (1μg/kg) with a two-weeks wash-out period between treatments. Blood samples were collected immediately before the injection, after 30 minutes, then after 1, 2, 3, 4, 5 and 6 hours. Two-way repeated measure analysis of variance (ANOVA) showed no significant effect of DDAVP vs placebo, except for white blood cell (WBC) count, and in particular on neutrophils. In conclusion, DDAVP administration in healthy donor dogs does not induce modification in blood cell count and clotting parameters, except of WBC.

Keywords: desmopressin; clotting time parameters; hemochromocytometric parameters; dog; blood donor

Received: July 2, 2009; Revised: July 20, 2009; Published: July 31, 2009  Show citation