J Appl Biomed 9:143-149, 2011 | DOI: 10.2478/v10136-009-0033-5

Gentamicin bound to the nanofibre microdispersed oxidized cellulose in the treatment of deep surgical site infections

Petr Lochman^1,2,*, Jiří Páral^1,2, Jaromír Kočí^2,3

¹ Department of Field Surgery, Faculty of Military Health Sciences, University of Defense, Hradec Králové, Czech Republic

² Department of Surgery, University Hospital, Hradec Králové, Czech Republic

³ Emergency Medicine Department, University Hospital, Hradec Králové, Czech Republic

The aim of this experimental in vivo study was to examine the effect of topically-used gentamicin bound to microdispersed oxidized cellulose (MDOC) in nanofibre form in the treatment of deep surgical site infections and to compare it with Garamycin Schwamm®. Twelve domestic swine were used in a model of a full-thickness infected dermal wound. The effectiveness of both forms of gentamicin were tested in wound infections caused by Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli. The effectiveness of gentamicin-MDOC and Garamycin Schwamm® were comparable according to microbiological culture findings, with no statistically significant differences. When macroscopically assessed, 100% of the infected wounds treated by gentamicin-MDOC were without signs of infection, compared with only 16.7% when Garamycin Schwamm® was used and this was of statistical significance. Therefore when combined with a nanofibre MDOC carrier, topically-used gentamicin is rendered more effective for the treatment of full-thickness skin infections.

Keywords: gentamicin; microdispersed oxidized cellulose; surgical site infections; Garamycin Schwamm

Received: June 7, 2010; Revised: September 17, 2010; Published: July 31, 2011  Show citation