J Appl Biomed 10:9-17, 2012 | DOI: 10.2478/v10136-011-0005-4

Influence of circulating fibrocytes on the growth, proliferation and migration of keratinocytes and fibroblasts

Peng Liu1,3,4, Gang Hu2,*, Jie Feng2, Yan Jin1,3
1 Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi'an, 710032, China
2 Department of Dermatology, Second Hospital of Xi'an Jiaotong University, Xi'an, 710004, China
3 Department of Oral Histology and Pathology, School of Stomatology, Fourth Military Medical University, Xi'an, 710032, China
4 Department of Stomatology, No. 201 Military Hospital of PLA, Liaoyang, 111000, China

Circulating fibrocytes (CFs) exhibit an extraordinary degree of plasticity and growth factor repertoire, and because of this they have been investigated for their role in the repair and regeneration of damaged tissues, but yet not adequately for their role in wound healing. In the present study, CFs were co-cultured with keratinocytes (KCs) or fibroblasts (Fbs) and the influences of CFs on the growth, proliferation and migration of KCs and Fbs were investigated. Our results showed that the CFs in the co-culture system could inhibit the growth, proliferation and migration of KCs, while CFs promoted the growth and proliferation of Fbs. Our study demonstrates that CFs can regulate the functions of Fbs, which may be a possible cause of fibrosis.

Keywords: circulating fibrocytes; cell interaction; keratinocytes; fibroblasts; wound healing

Received: March 3, 2011; Revised: October 12, 2011; Published: March 31, 2012  Show citation

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Liu P, Hu G, Feng J, Jin Y. Influence of circulating fibrocytes on the growth, proliferation and migration of keratinocytes and fibroblasts. J Appl Biomed. 2012;10(1):9-17. doi: 10.2478/v10136-011-0005-4.
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