J Appl Biomed 12:97-110, 2014 | DOI: 10.1016/j.jab.2013.01.002

Investigating the influence of taurine on thiol antioxidant status in Wistar rats with a multi-analytical approach

Jiri Sochora,b,c, Lukas Nejdla, Branislav Ruttkay-Nedeckya,b, Andrea Bezdekovaa, Katerina Lukesovad, Ondrej Zitkaa,b,c, Natalia Cerneia, Petr Maresd, Miroslav Pohankab,e, Vojtech Adama,b,c, Petr Babulaa,b, Miroslava Beklovab,f, Ladislav Zemand, Rene Kizeka,b,c,*
a Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Brno, Czech Republic
b Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic
c Department of Microelectronics, Faculty of Electrical Engineering and Communication, Brno University of Technology, Brno, Czech Republic
d Department of Animal Nutrition and Forage Production, Faculty of Agronomy, Mendel University in Brno, Brno, Czech Republic
e Centre of Advanced Studies and Department of Toxicology, Faculty of Military Health Sciences, University of Defence, Hradec Králové, Czech Republic
f Department of Veterinary Ecology and Environmental Protection, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic

Taurine (2-aminoethanesulfonic acid) is an organic acid widely distributed in animal tissues. It is involved in many physiological processes. Thus, it is widely discussed especially due to its antioxidant properties. In this study, we focused on the effect of taurine supplementation on the concentration of antioxidants in blood plasma and erythrocytes of Wistar rats. Taurine was applied in feed mixture in the dosage of 0, 1, 250, 500, 750, 1000, 1500, 2000, 2500, 3000, 3500 and 4000 mg/kg. We monitored both enzymatic and non-enzymatic antioxidants - glutathione peroxidase, glutathione reductase, and superoxide dismutase and reduced/oxidized glutathione and metallothionein. Using three different methods 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), Ferric Reducing Antioxidant Power (FRAP) and free radicals, we determined antioxidant capacity. In addition, we monitored levels of uric acid and glucose. Our results revealed significant changes in both enzymatic and non-enzymatic parameters with the increasing taurine supplementation.

Keywords: Taurine; Thiol antioxidant; Oxidative stress; Glutathione; Metallothionein; Wistar rats

Received: November 30, 2012; Revised: January 29, 2013; Accepted: January 29, 2013; Published: April 1, 2014  Show citation

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Sochor J, Nejdl L, Ruttkay-Nedecky B, Bezdekova A, Lukesova K, Zitka O, et al.. Investigating the influence of taurine on thiol antioxidant status in Wistar rats with a multi-analytical approach. J Appl Biomed. 2014;12(2):97-110. doi: 10.1016/j.jab.2013.01.002.
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