J Appl Biomed 13:273-277, 2015 | DOI: 10.1016/j.jab.2015.04.004

The effect of different doses of atropine on gastric myoelectrical activity in fasting experimental pigs

Jan Buresa, Jaroslav Kvetinaa, Ilja Tachecia, Michal Pavlikb, Martin Kunesc, Stanislav Rejchrta, Kamil Kucab,c,*, Marcela Kopacovaa
a Second Department of Internal Medicine - Gastroenterology, Charles University in Praha, Faculty of Medicine at Hradec Kralove, University Teaching Hospital, Hradec Kralove, Czech Republic
b Department of Toxicology and Military Pharmacy, Faculty of Military Health Services, University of Defence, Hradec Kralove, Czech Republic
c Biomedical Research Centre, University Teaching Hospital, Hradec Kralove, Czech Republic

Electrogastrography (EGG) is a non-invasive method for the assessment of gastric myoelectrical activity. Porcine EGG is comparable with human one. There are no data on the impact of moderate to high doses of atropine on EGG, neither in humans nor experimental pigs. The purpose of this study was to evaluate the effect of different doses of atropine on EGG in experimental pigs.
Six fasting pigs entered the study three times in a random order. The baseline EGG recording lasted 20 min, followed by a 105-min EGG trial recording. Intramuscular atropine 1.5 mg (part 1), 3.0 mg (part 2) and 4.5 mg (part 3) was administrated after the baseline EGG.
Atropine doses of 1.5 and 3.0 mg revealed a similar pattern in the EGG power course. After an initial increase (at the first 15-min interval), the areas of amplitudes decreased back to values comparable with basal levels and subsequently increased significantly again to the maximum at 105 min. The EGG power was quite different after the administration of 4.5 mg of atropine. Areas of amplitudes decreased gradually to the minimum values at 105 min after atropine administration.
In conclusion, different dose-dependent changes in the EGG pattern were found after moderate to high doses of atropine.

Keywords: Atropine; Electrogastrography; Experimental pigs; Gastric myoelectrical activity; Non-invasive method; Stomach

Received: January 4, 2015; Revised: April 26, 2015; Accepted: April 30, 2015; Published: November 1, 2015  Show citation

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Bures J, Kvetina J, Tacheci I, Pavlik M, Kunes M, Rejchrt S, et al.. The effect of different doses of atropine on gastric myoelectrical activity in fasting experimental pigs. J Appl Biomed. 2015;13(4):273-277. doi: 10.1016/j.jab.2015.04.004.
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