J Appl Biomed 14:85-90, 2016 | DOI: 10.1016/j.jab.2016.01.001

Carbamates pesticides induced immunotoxicity and carcinogenicity in human: A review

Ines Bini Dhouib^a,c,*, Alya Annabi^a, Manel Jallouli^a, Soumaya Marzouki^b, Najoua Gharbi^a, Saloua Elfazaa^a, Mohamed Montassar Lasram^a

^a Search unit of Aggression Physiology and Endocrine Metabolic Studies, Laboratoire de Microorganismes et Biomolécules actives, Département de Biologie, Faculté de Sciences de Tunis, Campus Universitaire, 2092 Tunis, Tunisia

^b Laboratory of Clinical Immunology, Pasteur Institute, Tunis, Tunisia

^c Arab University of Sciences, Tunis, Tunisia

In the literature, carbamates pesticides (CMs) have been implicated in the increasing prevalence of diseases associated with alterations of the immune response, such as hypersensitivity reactions, some autoimmune diseases and cancers. CMs may initiate, facilitate or exacerbate pathological immune processes, resulting in immunotoxicity by induction of mutations in genes coding for immunoregulatory factors and modifying immune tolerance. In the present study, oxidative stress and inhibition of esterases activities have been introduced as the main mechanisms of CMs induced immune dysregulation. In addition, the evidence on the relationship between CMs pesticide exposure, dysregulation of the immune system and predisposition to different types of cancers are criticized.

Keywords: Carbamates; Immune system; Cancer; Immunotoxicity; Human

Received: June 25, 2015; Revised: January 1, 2016; Accepted: January 4, 2016; Published: April 1, 2016  Show citation