J Appl Biomed 14:119-124, 2016 | DOI: 10.1016/j.jab.2015.10.002

Overt hypothyroidism is associated with blood inflammatory biomarkers dependent of lipid profile

Adriana Santia,b,*, Ivana Beatrice Mânica da Cruza,c, Vania Lucia Loroa, Marta Maria Medeiros Frescura Duarted, Fernanda Barbisanc, Thiago Duartec, Anahy Gabriela Pasae
a Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil
b Instituto de Ciências Exatas e Naturais, Curso de Medicina, Universidade Federal de Mato Grosso, Rondonópolis, MT, Brazil
c Laboratório de Biogenômica, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil
d Universidade Luterana do Brasil, BR 287 km 252, Santa Maria, RS, Brazil
e Laboratório Bergmann, Chapecó, SC, Brazil

To investigate the association between inflammatory biomarkers and overt hypothyroidism (OH). We measured inflammatory cytokines, interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) as well as cell-free DNA (cf-DNA) levels in 40 OH patients and 40 healthy controls. Total cholesterol, high and low density lipoprotein subfractions, triglyceride, fibrinogen, and D-dimer were recorded. Increased inflammatory profile was evidenced through significant elevations in the concentrations of all cytokines and cf-DNA levels in the OH group. Lipids and prothrombotic markers were also increased in hypothyroid subjects. A significant association between the inflammatory cytokines and lipid profile was observed. A multivariate analysis showed that this result was independent of the sex, age and BMI status of the subjects. Hypothyroidism is associated with proinflammatory state. Lipid abnormalities have a stronger influence on inflammation, increasing cardiovascular risk and atherosclerosis development in hypothyroidism.

Keywords: Hypothyroidism; Lipids; Cytokines; Inflammation; Cell-free DNA

Received: June 10, 2015; Revised: October 6, 2015; Accepted: October 8, 2015; Published: April 1, 2016  Show citation

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Santi A, da Cruz IBM, Loro VL, Medeiros Frescura Duarte MM, Barbisan F, Duarte T, Pasa AG. Overt hypothyroidism is associated with blood inflammatory biomarkers dependent of lipid profile. J Appl Biomed. 2016;14(2):119-124. doi: 10.1016/j.jab.2015.10.002.
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