J Appl Biomed 16:111-119, 2018 | DOI: 10.1016/j.jab.2017.11.002

Effect of pramipexole alginate nanodispersion (PAND) on the transgenic Drosophila expressing human alpha synuclein in the brain

Yasir Hasan Siddique^a,*, Falaq Naz^a, Wasi Khan^b, Smita Jyoti^a, Braj Raj Singh^c, Alim Hussain Naqvi^d

^a Aligarh Muslim University, Faculty of Life Sciences, Department of Zoology, Section of Genetics, Drosophila Transgenic Laboratory, Aligarh, India

^b Aligarh Muslim University, Faculty of Science, Department of Physics, Aligarh, India

^c TERI-Deakin Nanobiotechnology Centre, TERI Gram, The Energy and Resources Institute, Gurgaon, Haryana, India

^d Aligarh Muslim University, Interdisciplinary Nanotechnology Centre, Aligarh, India

In the present study the effect of pramipexole alginate nanodispersion (PAND) was studied on the transgenic Drosophila exhibiting the PD symptoms. The PD flies were allowed to feed on the diet having PAND at final concentration of 1, 2 and 3 μM. A dose dependent significant delay in the loss of climbing ability and improvement in the activity was observed in PD flies. A dose dependent significant change in the oxidative stress markers and dopamine content was also observed in the PD flies exposed to various doses PAND. The improvement in the PD symptoms was more in PD flies exposed to PAND compared to PD flies exposed to pramipexole alone.

Keywords: Pramipexole; Parkinson's disease; Oxidative stress; Drosophila melanogaster; Nanocomposite

Received: December 27, 2016; Revised: October 5, 2017; Accepted: November 21, 2017; Published: May 1, 2018  Show citation