J Appl Biomed 16:133-137, 2018 | DOI: 10.1016/j.jab.2017.11.007

Caveolin-1 rs4730751 gene polymorphism in kidney allograft recipients

Sylwia Słuczanowska-Głąbowska^a, Damian Malinowski^b, Krzysztof Safranow^c, Leszek Domański^d, Michał Czerewaty^a, Przemysław Ustianowski^e, Maria Laszczyńska^f, Andrzej Pawlik^a,*

^a Pomeranian Medical University, Department of Physiology, Szczecin, Poland

^b Pomeranian Medical University, Department of Pharmacokinetics and Therapeutic Drug Monitoring, Szczecin, Poland

^c Pomeranian Medical University, Department of Biochemistry and Medical Chemistry, Szczecin, Poland

^d Pomeranian Medical University, Department of Nephrology, Transplantology and Internal Medicine, Szczecin, Poland

^e Pomeranian Medical University, Department of Perinatology, Obstetrics and Gynecology, Police, Poland

^f Pomeranian Medical University, Department of Histology and Developmental Biology, Szczecin, Poland

Caveolin-1 is a phosphoprotein that plays a crucial role in tissue remodeling and fibrotic pathways, controlling fibroblast function, proliferation, and apoptosis. Here we aimed to examine the association between the CAV1 rs4730751 gene polymorphism and kidney graft function, graft histology, and graft survival. This study enrolled 270 Caucasian deceased - donor renal transplant recipients. We found no statistically significant associations between CAV1 rs4730751 and delayed graft function, acute rejection, or chronic allograft dysfunction, as well as creatinine values at 1-60 months after transplantation, the risk of graft loss, dialysis or death after transplantation, or histopathological changes in kidney allograft biopsies. Our findings do not support an association between the CAV1 gene rs4730751 polymorphism and kidney allograft function in our population.

Keywords: Caveolin-1; Gene; Polymorphism; Kidney; Allograft

Received: April 24, 2017; Revised: September 3, 2017; Accepted: November 24, 2017; Published: May 1, 2018  Show citation