J Appl Biomed 16:247-254, 2018 | DOI: 10.1016/j.jab.2018.05.005

Adipocytokines and new onset diabetes mellitus after transplantation

Dominika Goldmannová, Jaromíra Spurná, Ondřej Krystyník, Jan Schovánek, Lubica Cibičková, David Karásek, Josef Zadražil*
Palacký University Olomouc, Faculty of Medicine and Dentistry, University Hospital Olomouc, Department of Internal Medicine III - Nephrology, Rheumatology and Endocrinology, Olomouc, Czech Republic

Background and aim
Diabetes mellitus is a very common metabolic disease with a rising incidence. It is one of the most serious comorbidities in renal transplant recipients. New-onset diabetes after renal transplantation (NODAT) is associated with poor graft function, higher rates of cardiovascular complications and a poor prognosis. Adipocytokines, synthetized by adipose tissue influence metabolic pathways and disorders in various ways. In this review article, we chose the most researched adipocytokines and evaluated their relationship to posttransplant diabetes mellitus. The aim of this paper is to summarize current knowledge and discuss their perspective role in diagnostics or therapy of the new onset diabetes mellitus after transplantation.

Keywords: Diabetology; Transplantology; Adipocytokines; Adipose tissue; Insulin resistence; Insulin sensitivity

Received: December 10, 2017; Revised: April 19, 2018; Accepted: May 21, 2018; Published: November 1, 2018  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Goldmannová D, Spurná J, Krystyník O, Schovánek J, Cibičková L, Karásek D, Zadražil J. Adipocytokines and new onset diabetes mellitus after transplantation. J Appl Biomed. 2018;16(4):247-254. doi: 10.1016/j.jab.2018.05.005.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Adachi, H., Nakayama, K., Hayashi, N., Matsui, Y., Fujimoto, K., Yamaya, H., et al., 2016. Adiponectin fractions influence the development of posttransplant diabetes mellitus and cardiovascular disease in Japanese renal transplant recipients. PLoS One 11, e0163899. Go to original source... Go to PubMed...
    2. Al-azzam, S.I., Khabour, O.F., Alzoubi, K.H., Alzayadeen, R.N., 2014. The effect of leptin promoter and leptin receptor gene polymorphisms on lipid profile among the diabetic population: modulations by atorvastatin treatment and environmental factors. J. Endocrinol. Invest. 37, 835-842. Go to original source... Go to PubMed...
    3. Aldamiz-Echevarria, L., Sanjurjo, P., Vallo, A., Aguirre, M., Perez-Nanclares, G., Gimeno, P., et al., 2003. Genetic and metabolic determinants of increased plasma plasminogen activator inhibitor-1 activity in children with renal transplants. Pediatr. Nephrol. 18, 749-755. Go to original source... Go to PubMed...
    4. Alessi, M.C., Peiretti, F., Morange, P., Henry, M., Nalbone, G., Juhan-Vague, I., 1997. Production of plasminogen activator inhibitor 1 by human adipose tissue: possible link between visceral fat accumulation and vascular disease. Diabetes 46, 860-867. Go to original source... Go to PubMed...
    5. Bagheri, L., Hami, M., Mojahedi, M.-J., Ghorban Sabbagh, M., Ayatollahi, H., 2016. Association of metabolic syndrome with serum fibroblast growth factor 21 in kidney transplanted patients. J. Ren. Inj. Prev. 5, 79-84. Go to original source... Go to PubMed...
    6. Bayés, B., Granada, M.L., Pastor, M.C., Lauzurica, R., Salinas, I., Sanmartí, A., et al., 2007. Obesity, adiponectin and inflammation as predictors of new-onset diabetes mellitus after kidney transplantation. Am. J. Transplant. 7, 416-422. Go to original source... Go to PubMed...
    7. Berg, A., Combs, T., Du, X., Brownlee, M., Scherer, P., 2001. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat. Med. 7, 947-953. Go to original source... Go to PubMed...
    8. Björntorp, P., Sjöström, L., 1971. Number and size of adipose tissue fat cells in relation to metabolism in human obesity. Metabolism 20, 703-713. Go to original source... Go to PubMed...
    9. Blüher, M., 2009. Adipose tissue dysfunction in obesity. Exp. Clin. Endocrinol. Diabetes 117, 241-250. Go to original source... Go to PubMed...
    10. Blüher, M., 2013a. Adipose tissue dysfunction contributes to obesity related metabolic diseases. Best Pract. Res. Clin. Endocrinol. Metab. 27, 163-177. Go to original source... Go to PubMed...
    11. Blüher, M., 2013b. Importance of adipokines in glucose homeostasis. Diabetes Manag. 3, 389-400. Go to original source...
    12. Blüher, M., 2014. Adipokines - removing road blocks to obesity and diabetes therapy. Mol. Metab. 3, 230-240. Go to original source... Go to PubMed...
    13. Blüher, M., Kratzsch, J., Paschke, R., 2001. Plasma levels of tumor necrosis factoralpha, angiotensin II, growth hormone, and IGF-I are not elevated in insulinresistant obese individuals with impaired glucose tolerance. Diabetes Care 24, 328-334. Go to original source... Go to PubMed...
    14. Blüher, M., Mantzoros, C.S., 2015. From leptin to other adipokines in health and disease: facts and expectations at the beginning of the 21st century. Metabolism 64, 131-145. Go to original source... Go to PubMed...
    15. Boucher, J., Masri, B., Daviaud, D., Gesta, S., Guigné, C., Mazzucotelli, A., et al., 2005. Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinology 146, 1764-1771. Go to original source... Go to PubMed...
    16. Brown, J.E.P., Conner, A.C., Digby, J.E., Ward, K.L., Ramanjaneya, M., Randeva, H.S., Dunmore, S.J., 2010. Regulation of beta-cell viability and gene expression by distinct agonist fragments of adiponectin. Peptides 31, 944-949. Go to original source... Go to PubMed...
    17. Cao, J., Li, H., Chen, L., 2015. Targeting drugs to APJ receptor: the prospect of treatment of hypertension and other cardiovascular diseases. Curr. Drug Targets 16, 148-155. Go to original source... Go to PubMed...
    18. Castan-Laurell, I., Dray, C., Attané, C., Duparc, T., Knauf, C., Valet, P., 2011. Apelin, diabetes, and obesity. Endocrine 40, 1-9. Go to original source... Go to PubMed...
    19. Cawthorn, W.P., Sethi, J.K., 2008. TNF-alpha and adipocyte biology. FEBS Lett. 582, 117-131. Go to original source... Go to PubMed...
    20. Cha, J.J., Min, H.S., Kim, K., Lee, M.J., Kim, J.E., Song, H.K., et al., 2018. Long term study of the association of adipokines and glucose variability with diabetic complications. Korean J. Intern. Med. 33, 367-382. Go to original source... Go to PubMed...
    21. Chadban, S., 2008. New-onset diabetes after transplantation - should it be a factor in choosing an immunosuppressant regimen for kidney transplant recipients. Nephrol. Dial. Transplant. 23, 1816-1818. Go to original source... Go to PubMed...
    22. Chang, H.-R., Yang, S.-F., Lian, J.-D., Lin, C.-C., Wen, M.-C., Chen, Y.T., et al., 2009. Prediction of chronic allograft damage index of renal allografts using serum level of plasminogen activator inhibitor-1. Clin. Transplant. 23, 206-212. Go to original source... Go to PubMed...
    23. Chang, H.R., Yang, S.F., Tsai, J.P., Hsieh, M.C., Wu, S.W., Tsai, H.C., et al., 2011. Plasminogen activator inhibitor-1 5G/5G genotype is a protecting factor preventing posttransplant diabetes mellitus. Clin. Chim. Acta 412, 322-326. Go to original source... Go to PubMed...
    24. Chen, C.C., Li, T.C., Li, C.I., Liu, C.S., Wang, H.J., Lin, C.C., 2005. Serum resistin level among healthy subjects: relationship to anthropometric and metabolic parameters. Metabolism 54, 471-475. Go to original source... Go to PubMed...
    25. Chetboun, M., Abitbol, G., Rozenberg, K., Rozenfeld, H., Deutsch, A., Sampson, S.R., Rosenzweig, T., 2012. Maintenance of redox state and pancreatic beta-cell function: role of leptin and adiponectin. J. Cell. Biochem. 113, 1966-1976. Go to original source... Go to PubMed...
    26. Clarke, D.K., Mohamed-Ali, V., 2005. Adipokines and insulin resistance. Insulin Resistance: Insulin Action and Its Disturbances in Disease, doi:http://dx.doi. org/10.1002/0470011327.ch10. Go to original source...
    27. Cnop, M., Havel, P.J., Utzschneider, K.M., Carr, D.B., Sinha, M.K., Boyko, E.J., et al., 2003. Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia 46, 459-469. Go to original source... Go to PubMed...
    28. Cosio, F.G., Pesavento, T.E., Osei, K., Henry, M.L., Ferguson, R.M., 2001. Posttransplant diabetes mellitus: increasing incidence in renal allograft recipients transplanted in recent years. Kidney Int. 59, 732-737. Go to original source... Go to PubMed...
    29. Cotillard, A., Poitou, C., Torcivia, A., Bouillot, J.L., Dietrich, A., Klöting, N., et al., 2014. Adipocyte size threshold matters: link with risk of type 2 diabetes and improved insulin resistance after gastric bypass. J. Clin. Endocrinol. Metab. 99, E1466-1470. Go to original source... Go to PubMed...
    30. Davidson, J.A., Wilkinson, A., 2004. New-onset diabetes after transplantation 2003 international consensus guidelines: an endocrinologist's view. Diabetes Care 27, 805-812. Go to original source... Go to PubMed...
    31. Degawa-Yamauchi, M., Bovenkerk, J.E., Juliar, B.E., Watson, W., Kerr, K., Jones, R., et al., 2003. Serum resistin (FIZZ3) protein is increased in obese humans. J. Clin. Endocrinol. Metab. 88, 5452-5455. Go to original source... Go to PubMed...
    32. Drachenberg, C.B., Klassen, D.K., Weir, M.R., Wiland, A., Fink, J.C., Bartlett, S.T., et al., 1999. Islet cell damage associated with tacrolimus and cyclosporine: morphological features in pancreas allograft biopsies and clinical correlation. Transplantation 68, 396-402. Go to original source... Go to PubMed...
    33. El Haggan, W., Chauveau, P., Barthe, N., Merville, P., Potaux, L., Aparicio, M., 2004. Serum leptin, body fat, and nutritional markers during the six months postkidney transplantation. Metabolism 53, 614-619. Go to original source... Go to PubMed...
    34. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus, 2003. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 26 (Suppl. 1), S5-S20. Go to original source... Go to PubMed...
    35. Fasshauer, M., Blüher, M., Stumvoll, M., 2014. Adipokines in gestational diabetes. Lancet Diabetes Endocrinol. 2, 488-499. Go to original source... Go to PubMed...
    36. Friedman, J.M., Halaas, J.L., 1998. Leptin and the regulation of body weight in mammals. Nature 395, 763-770. Go to original source... Go to PubMed...
    37. Fruebis, J., 2001. Proteolytic cleavage product of 30-kDa adipocyte complementrelated protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc. Natl. Acad. Sci. 98, 2005-2010. Go to original source... Go to PubMed...
    38. Frühbeck, G., Méndez-Giménez, L., Fernández-Formoso, J.-A., Fernández, S., Rodríguez, A., 2014. Regulation of adipocyte lipolysis. Nutr. Res. Rev. 27, 63-93. Go to original source... Go to PubMed...
    39. Fukuhara, A., 2005. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 307, 426-430. Go to original source... Go to PubMed...
    40. Gaich, G., Chien, J.Y., Fu, H., Glass, L.C., Deeg, M.A., Holland, W.L., et al., 2013. The effects of LY2405319, an FGF21 Analog, in obese human subjects with type 2 diabetes. Cell. Metab. 18, 333-340. Go to original source... Go to PubMed...
    41. Gerber, M., Boettner, A., Seidel, B., Lammert, A., Bär, J., Schuster, E., et al., 2005. Serum resistin levels of obese and lean children and adolescents: biochemical analysis and clinical relevance. J. Clin. Endocrinol. Metab. 90, 4503-4509. Go to original source... Go to PubMed...
    42. Gnacinska, M., Małgorzewicz, S., Łysiak-Szydłowska, W., Sworczak, K., 2010. The serum profile of adipokines in overweight patients with metabolic syndrome. Endokrynol. Pol. 61, 36-41. Go to PubMed...
    43. Hanley, A.J.G., Bowden, D., Wagenknecht, L.E., Balasubramanyam, A., Langfeld, C., Saad, M.F., et al., 2007. Associations of adiponectin with body fat distribution and insulin sensitivity in nondiabetic Hispanics and African-Americans. J. Clin. Endocrinol. Metab. 92, 2665-2671. Go to original source... Go to PubMed...
    44. Hara, K., Boutin, P., Mori, Y., Tobe, K., Dina, C., Yasuda, K., et al., 2002. Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 51, 536-540. Go to original source... Go to PubMed...
    45. Heiker, J.T., Klöting, N., Kovacs, P., Kuettner, E.B., Sträter, N., Schultz, S., et al., 2013. Vaspin inhibits kallikrein 7 by serpin mechanism. Cell. Mol. Life Sci. 70, 2569- 2583. Go to original source... Go to PubMed...
    46. Heilbronn, L.K., Rood, J., Janderova, L., Albu, J.B., Kelley, D.E., Ravussin, E., Smith, S.R., 2004. Relationship between serum resistin concentrations and insulin resistance in nonobese, obese, and obese diabetic subjects. J. Clin. Endocrinol. Metab. 89, 1844-1848. Go to original source... Go to PubMed...
    47. Heisel, O., Heisel, R., Balshaw, R., Keown, P., 2004. New onset diabetes mellitus in patients receiving calcineurin inhibitors: a systematic review and metaanalysis. Am. J. Transplant. 4, 583-595. Go to original source... Go to PubMed...
    48. Herlihy, O., Barrow, B., Grant, P., Levy, J., 2002. Hyperglycaemic siblings of Type II (noninsulin-dependent) diabetic patients have increased PAI-1, central obesity and insulin resistance compared with their paired normoglycaemic sibling. Diabetologia 45, 635-641. Go to original source... Go to PubMed...
    49. Hoffsted, J., Eriksson, P., Mottagui-Tabar, S., Arner, P., 2002. A polymorphism in the leptin promoter region (-2548 G/A) influences gene expression and adipose tissue secretion of leptin. Horm. Metab. Res. 34, 355-359. Go to original source... Go to PubMed...
    50. Hotamisligil, G.S., Shargill, N.S., Spiegelman, B.M., 1993. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259, 87-91. Go to original source... Go to PubMed...
    51. Hotta, K., Funahashi, T., Bodkin, N.L., Ortmeyer, H.K., Arita, Y., Hansen, B.C., Matsuzawa, Y., 2001. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50, 1126-1133. Go to original source... Go to PubMed...
    52. Hu, E., Liang, P., Spiegelman, B.M., 1996. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J. Biol. Chem. 271, 10697-10703. Go to original source... Go to PubMed...
    53. Juhan-Vague, I., Alessi, M.C., Morange, P.E., 2000. Hypofibrinolysis and increased PAI-1 are linked to atherothrombosis via insulin resistance and obesity. Ann. Med. 32 (Suppl. 1), 78-84. Go to PubMed...
    54. Kaisar, M.O., Armstrong, K., Hawley, C., Campbell, S., Mudge, D., Johnson, D.W., et al., 2009. Adiponectin is associated with cardiovascular disease in male renal transplant recipients: baseline results from the LANDMARK 2 study. BMC Nephrol. 10, 29. Go to original source... Go to PubMed...
    55. Kang, E., Magkos, F., Kim, B., Zhai, R., Su, L., Kim, Y., et al., 2012. Variants of the adiponectin and adiponectin receptor-1 genes and posttransplantation diabetes mellitus in renal allograft recipients. J. Clin. Endocrinol. Metab. 97, E129-E135. Go to original source... Go to PubMed...
    56. Kasiske, B.L., Snyder, J.J., Gilbertson, D., Matas, A.J., 2003. Diabetes mellitus after kidney transplantation in the United States. Am. J. Transpl. 3, 178-185. Go to original source... Go to PubMed...
    57. Kayacan, S.M., Yildiz, A., Kazancioglu, R., Sahin, S., Sever, M.S., Ark, E., 2003. The changes in serum leptin, body fat mass and insulin resistance after renal transplantation. Clin. Transplant. 17, 63-68. Go to original source... Go to PubMed...
    58. Kharroubi, I., Rasschaert, J., Eizirik, D.L., Cnop, M., 2003. Expression of adiponectin receptors in pancreatic β cells. Biochem. Biophys. Res. Commun. 312, 1118-1122. Go to original source... Go to PubMed...
    59. Kielstein, J.T., Becker, B., Graf, S., Brabant, G., Haller, H., Fliser, D., 2003. Increased resistin blood levels are not associated with insulin resistance in patients with renal disease. Am. J. Kidney Dis. 42, 62-66. Go to original source... Go to PubMed...
    60. Kim, D.S., Kang, S., Moon, N.R., Park, S., 2014. Central visfatin potentiates glucosestimulated insulin secretion and β-cell mass without increasing serum visfatin levels in diabetic rats. Cytokine 65, 159-166. Go to original source... Go to PubMed...
    61. Klöting, N., Blüher, M., 2014. Adipocyte dysfunction, inflammation and metabolic syndrome. Rev. Endocr. Metab. Disord. 15, 277-287. Go to original source... Go to PubMed...
    62. Kokot, F., Adamczak, M., Wiecek, A., Spiechowicz, U., Mesjasz, J., 1999. Plasma immunoreactive leptin and neuropeptide Y levels in kidney transplant patients. Am. J. Nephrol. 19, 28-33. Go to original source... Go to PubMed...
    63. Krentz, A.J., Dmitrewski, J., Mayer, D., Nattrass, M., 1995. Effects of immunosuppressive agents on glucose metabolism: implications for the development of post-transplant diabetes mellitus. Clin. Immunother. 4, 103- 123. Go to original source...
    64. Krist, J., Wieder, K., Klöting, N., Oberbach, A., Kralisch, S., Wiesner, T., et al., 2013. Effects of weight loss and exercise on apelin serum concentrations and adipose tissue expression in human obesity. Obes. Facts 6, 57-69. Go to original source... Go to PubMed...
    65. Kuba, K., Zhang, L., Imai, Y., Arab, S., Chen, M., Maekawa, Y., et al., 2007. Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload. Circ. Res. 101, e32-42. Go to original source... Go to PubMed...
    66. Kusminski, C.M., Scherer, P.E., 2009. The road from discovery to clinic: adiponectin as a biomarker of metabolic status. Clin. Pharmacol. Ther. 86, 592-595. Go to original source... Go to PubMed...
    67. Lee, J.H., Chan, J.L., Yiannakouris, N., Kontogianni, M., Estrada, E., Seip, R., et al., 2003. Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: crosssectional and interventional studies in normal, insulin-resistant, and diabetic subjects. J. Clin. Endocrinol. Metab. 88, 4848-4856. Go to original source... Go to PubMed...
    68. Lehr, S., Hartwig, S., Sell, H., 2012. Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders. Proteom. Clin. Appl. 6, 91-101. Go to original source... Go to PubMed...
    69. LeRoith, D., Roberts Jr., C.T., 2003. The insulin-like growth factor system and cancer. Cancer Lett. 195, 127-137. Go to original source... Go to PubMed...
    70. Li, H., Wu, G., Fang, Q., Zhang, M., Hui, X., Sheng, B., et al., 2018. Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat. Nat. Commun. 9, 272. Go to original source... Go to PubMed...
    71. Li, Q.Y., Li, F., Sun, J.H., Chi, Y.Y., Yin, H.S., Liu, S.Q., Mei, Y.H., 2009. Mechanisms of diabetes mellitus induced with FK506 in SD rats models. Immunopharmacol. Immunotoxicol. 31, 675-681. Go to original source... Go to PubMed...
    72. Liu, M., Liu, F., 2014. Regulation of adiponectin multimerization, signaling and function. Best. Pract. Res. Clin. Endocrinol. Metab. 28, 25-31. Go to original source... Go to PubMed...
    73. Luan, F.L., Steffick, D.E., Ojo, A.O., 2011. New-onset diabetes mellitus in kidney transplant recipients discharged on steroid-free immunosuppression. Transplantation 91, 334-341. Go to original source... Go to PubMed...
    74. Małgorzewicz, S., Debska-Slizien, A., Czajka, B., Owczarzak, A., Rutkowski, B., 2016. Influence of body mass on kidney graft function in patients after kidney transplantation. Transplant. Proc. 5, 1472-1476. Go to original source... Go to PubMed...
    75. Malgorzewicz, S., Debska-Slizien, A., Czajka, B., Rutkowski, B., 2014. Adipokines and nutritional status in kidney transplant recipients. Transplant. Proc. 46, 2622- 2626. Go to original source... Go to PubMed...
    76. Mammès, O., Betoulle, D., Aubert, R., Herbeth, B., Siest, G., Fumeron, F., 2000. Association of the G-2548A polymorphism in the 5' region of the LEP gene with overweight. Ann. Hum. Genet. 64, 391-394. Go to original source... Go to PubMed...
    77. Mulvihill, E.E., Drucker, D.J., 2014. Pharmacology, physiology, and mechanisms of action of dipeptidyl peptidase-4 inhibitors. Endocr. Rev. 35, 992-1019. Go to original source... Go to PubMed...
    78. Nagy, K., Nagaraju, S.P., Rhee, C.M., Mathe, Z., Molnar, M.Z., 2016. Adipocytokines in renal transplant recipients. Clin. Kidney J. 9, 359-373. Go to original source... Go to PubMed...
    79. Nicoletto, B.B., Souza, G.C., Fonseca, N.K., Centenaro, A., Manfro, R.C., Canani, L.H., Goncalves, L.F., 2013. Association between 276G/T adiponectin gene polymorphism and new-onset diabetes after kidney transplantation. Transplantation 96, 1059-1064. Go to original source... Go to PubMed...
    80. Ocak, N., Dirican, M., Ersoy, A., Sarandol, E., 2016. Adiponectin, leptin, nitric oxide, and C-reactive protein levels in kidney transplant recipients: comparison with the hemodialysis and chronic renal failure. Ren. Fail. 38, 1639-1646. Go to original source... Go to PubMed...
    81. Ochi, M., Osawa, H., Hirota, Y., Hara, K., Tabara, Y., Tokuyama, Y., et al., 2007. Frequency of the G/G genotype of resistin single nucleotide polymorphism at -420 appears to be increased in younger-onset type 2 diabetes. Diabetes 56, 2834-2838. Go to original source... Go to PubMed...
    82. Ofei, F., Hurel, S., Newkirk, J., Sopwith, M., Taylor, R., 1996. Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM. Diabetes 45, 881-885. Go to original source... Go to PubMed...
    83. Olszanecka-Glinianowicz, M., Owczarek, A., Bozentowicz-Wikarek, M., Brzozowska, A., Mossakowska, M., Zdrojewski, T., et al., 2014. Relationship between circulating visfatin/NAMPT, nutritional status and insulin resistance in an elderly population - results from the PolSenior substudy. Metabolism 63, 1409- 1418. Go to original source... Go to PubMed...
    84. Osawa, H., Tabara, Y., Kawamoto, R., Ohashi, J., Ochi, M., Onuma, H., et al., 2007. Plasma resistin, associated with single nucleotide polymorphism -420, is correlated with insulin resistance, lower HDL cholesterol, and high-sensitivity C-reactive protein in the Japanese general population. Diabetes Care 30, 1501- 1506. Go to original source... Go to PubMed...
    85. Osawa, H., Yamada, K., Onuma, H., Murakami, A., Ochi, M., Kawata, H., et al., 2004. The G/G genotype of a resistin single-nucleotide polymorphism at À420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3. Am. J. Hum. Genet. 75, 678-686. Go to original source... Go to PubMed...
    86. Paquot, N., Castillo, M.J., Lefebvre, P.J., Scheen, A.J., 2000. No Increased insulin sensitivity after a single intravenous administration of a recombinant human tumor necrosis factor receptor: Fc fusion protein in obese insulin-resistant patients. J. Clin. Endocrinol. Metab. 85, 1316-1319. Go to original source...
    87. Pfützner, A., Langenfeld, M., Kunt, T., Löbig, M., Forst, T., 2003. Evaluation of human resistin assays with serum from patients with type 2 diabetes and different degrees of insulin resistance. Clin. Lab. 49, 571-576. Go to PubMed...
    88. Ren, J., 2004. Leptin and hyperleptinemia - from friend to foe for cardiovascular function. J. Endocrinol. 181, 1-10. Go to original source... Go to PubMed...
    89. Romanowski, M., Dziedziejko, V., Maciejewska-Karlowska, A., Sawczuk, M., Safranow, K., Domanski, L., Pawlik, A., 2015. Adiponectin and leptin gene polymorphisms in patients with post-transplant diabetes mellitus. Pharmacogenomics 16, 1243-1252. Go to original source... Go to PubMed...
    90. Sahin, D.S., Tumer, C., Demir, C., Celik, M.M., Celik, M., Ucar, E., Gunesacar, R., 2013. Association with leptin gene C.-2548 G&A polymorphism, serum leptin levels, and body mass index in Turkish obese patients. Cell. Biochem. Biophys. 65, 243-247. Go to original source... Go to PubMed...
    91. Samad, F., Loskutoff, D.J., 1996. Tissue distribution and regulation of plasminogen activator inhibitor-1 in obese mice. Mol. Med. 2, 568-582. Go to original source... Go to PubMed...
    92. Samal, B., Sun, Y., Stearns, G., Xie, C., Suggs, S., McNiece, I., 1994. Cloning and characterization of the cDNA encoding a novel human pre-B-cell colonyenhancing factor. Mol. Cell. Biol. 14, 1431-1437. Go to original source... Go to PubMed...
    93. Sandhu, M.S., Gibson, J.M., Heald, A.H., Dunger, D.B., Wareham, N.J., 2003. Low circulating IGF-II concentrations predict weight gain and obesity in humans. Diabetes 52, 1403-1408. Go to original source... Go to PubMed...
    94. Schold, J., Kaplan, B., Chumbler, N.R., Howard, R.J., Srinivas, T.R., Ma, L., MeierKriesche, H.U., 2005. Access to quality: evaluation of the allocation of deceased donor kidneys for transplantation. JASN 16, 3121-3127. Go to original source... Go to PubMed...
    95. Shimomura, I., Funahashi, T., Takahashi, M., Maeda, K., Kotani, K., Nakamura, T., et al., 1996. Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Nat. Med. 2, 800-803. Go to original source... Go to PubMed...
    96. Shu, K.H., Wu, M.J., Chen, C.H., Cheng, C.H., Yu, T.M., Chuang, Y.W., et al., 2014. Serum adipokine levels in renal transplant recipients. Transplant. Proc. 46, 381-384. Go to original source... Go to PubMed...
    97. Souza, G.C., Costa, C., Scalco, R., Goncalves, L.F., Manfro, R.C., 2008. Serum leptin, insulin resistance, and body fat after renal transplantation. J. Ren. Nutr. 18, 479-488. Go to original source... Go to PubMed...
    98. Stanley, T.L., Zanni, M.V., Johnsen, S., Rasheed, S., Makimura, H., Lee, H., et al., 2011. TNF-alpha antagonism with etanercept decreases glucose and increases the proportion of high molecular weight adiponectin in obese subjects with features of the metabolic syndrome. J. Clin. Endocrinol. Metab. 96, E146-150. 't Hart, L.M., Fritsche, A., Rietveld, I., Dekker, J.M., Nijpels, G., Machicao, F., et al., 2004. Genetic factors and insulin secretion: gene variants in the IGF genes. Diabetes 53 (Suppl. 1), S26-30. Go to original source... Go to PubMed...
    99. Tacke, F., Wüstefeld, T., Horn, R., Luedde, T., Rao, A.S., Manns, M.P., et al., 2005. High adiponectin in chronic liver disease and cholestasis suggests biliary route of adiponectin excretion in vivo. J. Hepatol. 42, 666-673. Go to original source... Go to PubMed...
    100. Tsai, J.P., Lee, M.C., Chen, Y.C., Ho, G.J., Shih, M.H., Hsu, B.G., 2015. Hyperleptinemia is a risk factor for the development of central arterial stiffness in kidney transplant patients. Transplant. Proc. 47, 1825-1830. Go to original source... Go to PubMed...
    101. Tschritter, O., Fritsche, A., Thamer, C., Haap, M., Shirkavand, F., Rahe, S., et al., 2003. Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism. Diabetes 52, 239-243. Go to original source... Go to PubMed...
    102. Van Gaal, L.F., Mertens, I.L., De Block, C.E., 2006. Mechanisms linking obesity with cardiovascular disease. Nature 444, 875-880. Go to original source... Go to PubMed...
    103. Vattam, K.K., Khan, I.A., Movva, S., Mukkavali, K.K., Poornima, S., Rao, P., et al., 2013. IGF2 ApaI A/G polymorphism evaluated in ESRD individuals as a biomarker to identify patients with new onset diabetes mellitus after renal transplant in Asian Indians. Open J. Nephrol. 2013, 104-108. Go to original source...
    104. Wente, W., Efanov, A.M., Brenner, M., Kharitonenkov, A., Köster, A., Sandusky, G.E., et al., 2006. Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways. Diabetes 55, 2470-2478. Go to original source... Go to PubMed...
    105. Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R.E., Tataranni, P.A., 2001. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J. Clin. Endocrinol. Metab. 86, 1930-1935. Go to original source... Go to PubMed...
    106. Wissing, K.M., Abramowicz, D., Weekers, L., Budde, K., Rath, T., Witzke, O., Broeders, N., Kianda, M., Kuypers, D.R.J., 2018. Prospective randomized study of conversion from tacrolimus to cyclosporine A to improve glucose metabolism in patients with posttransplant diabetes mellitus after renal transplantation. Am. J. Transplant. doi:http://dx.doi.org/10.1111/ajt.14665. Go to original source... Go to PubMed...
    107. Xiang, R.L., Mei, M., Su, Y.C., Li, L., Wang, J.Y., Wu, L.L., 2015. Visfatin protects rat pancreatic β-cells against IFN-g-induced apoptosis through AMPK and ERK1/2 signaling pathways. Biomed. Environ. Sci. 28, 169-177.
    108. Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., et al., 2001. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 7, 941-946. Go to original source... Go to PubMed...
    109. Yazdani-Biuki, B., Stelzl, H., Brezinschek, H.P., Hermann, J., Mueller, T., Krippl, P., et al., 2004. Improvement of insulin sensitivity in insulin resistant subjects during prolonged treatment with the anti-TNF-alpha antibody infliximab. Eur. J. Clin. Invest. 34, 641-642. Go to original source... Go to PubMed...
    110. Youn, B.-S., Yu, K.-Y., Park, H.J., Lee, N.S., Min, S.S., Youn, M.Y., et al., 2004. Plasma resistin concentrations measured by enzyme linked immunosorbent assay using a newly developed monoclonal antibody are elevated in individuals with type 2 diabetes mellitus. J. Clin. Endocrinol. Metab. 89, 150-156. Go to original source... Go to PubMed...
    111. Yu, A.-R., Xin, H.-W., Wu, X.-C., Fan, X., Liu, H.-M., Li, G., Bai, Y., 2011. Adiponectin gene polymorphisms are associated with posttransplantation diabetes mellitus in Chinese renal allograft recipients. Transplant. Proc. 43, 1607-1611. Go to original source... Go to PubMed...
    112. Yue, P., Jin, H., Xu, S., Aillaud, M., Deng, A.C., Azuma, J., et al., 2011. Apelin decreases lipolysis via G(q), G(i), and AMPK dependent mechanisms. Endocrinology 152, 59-68. Go to original source... Go to PubMed...
    113. Zoccali, C., Mallamaci, F., Tripepi, G., Benedetto, F.A., Cutrupi, S., Parlongo, S., et al., 2002. Adiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal disease. J. Am. Soc. Nephrol. 13, 134-141. Go to original source... Go to PubMed...

    Return to the content