J Appl Biomed 17:91-98, 2019 | DOI: 10.32725/jab.2019.006

MR compatible ergometers for dynamic 31P MRS

Petr Sedivy1, Monika Dezortova1, Jan Rydlo1, Miloslav Drobny1, Martin Kr¹¹įk2,3, Ladislav Valkovič4,5, Milan Hajek1,*
1 Institute for Clinical and Experimental Medicine, Department of Diagnostic and Interventional Radiology, MR-unit, Prague, Czech Republic
2 Medical University of Vienna, Department of Internal Medicine III & High Field MR Centre, Division of Endocrinology and Metabolism, Department of Biomedical Imaging and Image guided Therapy, Vienna, Austria
3 Christian Doppler Laboratory for Clinical Molecular MR Imaging (MOLIMA), Vienna, Austria
4 University of Oxford, RDM Cardiovascular Medicine, Oxford Centre for Clinical MR Research (OCMR), Oxford, United Kingdom
5 Slovak Academy of Sciences, Institute of Measurement Science, Department of Imaging Methods, Bratislava, Slovakia

Magnetic Resonance (MR) compatible ergometers are specialized ergometers used inside the MR scanners for the characterization of tissue metabolism changes during physical stress. They are most commonly used for dynamic phosphorous magnetic resonance spectroscopy (31P MRS), but can also be used for lactate production measurements, perfusion studies using arterial spin labelling or muscle oxygenation measurements by blood oxygen dependent contrast sequences. We will primarily discuss the importance of ergometers in the context of dynamic 31P MRS. Dynamic 31P MRS can monitor muscle fatigue and energy reserve during muscle contractions as well as the dynamics of recuperation of skeletal muscle tissue during the following recovery through signal changes of phosphocreatine (PCr), inorganic phosphate and adenosine triphosphate (ATP). Based on the measured data it is possible to calculate intracellular pH, metabolic flux of ATP through creatine-kinase reaction, anaerobic glycolysis and oxidative phosphorylation and other metabolic parameters as mitochondrial capacity. This review primarily focuses on describing various technical designs of MR compatible ergometers for dynamic 31P MRS that must be constructed with respect to the presence of magnetic field. It is also expected that the construction of ergometers will be easy for the handling and well accepted by examined subjects.

Keywords: Dynamic 31P magnetic resonance spectroscopy; Exercise; MR ergometer; Muscle examination
Grants and funding:

The study was supported by the Ministry of Health of the Czech Republic: AZV 15-26906A and MHCZ-DRO 00023001 IKEM and the Ministry of Education, Youth and Sports: MOBILITY Czech-Austria 8J18AT023. The support from the Sir Henry Dale Fellowship from the Wellcome Trust and the Royal Society (grant #098436/Z/12/B) and from the Slovak Grant Agencies VEGA (grant #2/0001/17) and APVV (grant #15-0029) is also gratefully acknowledged.

Conflicts of interest:

The authors have no conflict of interests to declare.

Received: January 21, 2019; Accepted: April 15, 2019; Prepublished online: April 15, 2019; Published: June 28, 2019  Show citation

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Sedivy P, Dezortova M, Rydlo J, Drobny M, Kr¹¹įk M, Valkovič L, Hajek M. MR compatible ergometers for dynamic 31P MRS. J Appl Biomed. 2019;17(2):91-98. doi: 10.32725/jab.2019.006. PubMed PMID: 34907736.
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