J Appl Biomed 17:147-156, 2019 | DOI: 10.32725/jab.2019.012

Identification and applications of neuroactive silk proteins: a narrative review

Ahad Banagozar Mohammadi1,2, Saeed Sadigh-Eteghad2, Mohammadali Torbati3, Seyyed Mohammad Bagher Fazljou1, Seyed Mehdi Vatandoust2, Samad EJ Golzari4,5, Fereshteh Farajdokht2,*, Javad Mahmoudi2,*
1 Tabriz University of Medical Sciences, Faculty of Traditional Medicine, Department of Traditional Medicine, Tabriz, Iran
2 Tabriz University of Medical Sciences, Neurosciences Research Center (NSRC), Tabriz, Iran
3 Tabriz University of Medical Sciences, Faculty of Nutrition, Department of Food Science and Technology, Tabriz, Iran
4 Tabriz University of Medical Sciences, Research Center for Evidence Based Medicine, Tabriz, Iran
5 Tabriz University of Medical Sciences, Health Management and Safety Promotion Research Institute, Road Traffic Injury Research Center, Tabriz, Iran

In traditional medicine, natural silk is regarded as a cognitive enhancer and a cure for ameliorating the symptoms of heart disease, atherosclerosis, and metabolic disorders. In this review, general characteristics of both silk proteins, fibroin and sericin, extracted from silkworm Bombyx mori and their potential use in the neuronal disorders was discussed. Evidence shows that silk proteins exhibit neuroprotective effects in models of neurotoxicity. The antioxidant, neuroprotective, and acetylcholinesterase inhibitory mechanisms of silk proteins could prove promising in the treatment of neurodegenerative diseases. Owing to their excellent neurocompatibility and physicochemical properties, silk proteins have been used as scaffolds and drug delivery materials in the neuronal tissue engineering. These data support the potential of silk proteins as an effective complementary agent for central and peripheral neurological disorders.

Keywords: Fibroin; Neuroprotection; Sericin; Silk proteins
Grants and funding:

This study was financially supported by a grant from Vice-Chancellor for Research of Tabriz University of Medical Sciences, Tabriz, Iran (Grant No. 59935).

Conflicts of interest:

The authors have no conflict of interests to declare.

Received: March 13, 2019; Accepted: March 20, 2019; Prepublished online: August 14, 2019; Published: September 18, 2019  Show citation

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Banagozar Mohammadi A, Sadigh-Eteghad S, Torbati M, Bagher Fazljou SM, Vatandoust SM, EJ Golzari S, et al.. Identification and applications of neuroactive silk proteins: a narrative review. J Appl Biomed. 2019;17(3):147-156. doi: 10.32725/jab.2019.012. PubMed PMID: 34907702.
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