Journal of Applied Biomedicine, 2019 (vol. 17), issue 3
Reshaping cortical activity with subthalamic stimulation in Parkinson's disease during finger tapping and gait mapped by near infrared spectroscopy
Ondrej Klempir, Radim Krupicka, Jan Mehnert, Vaclav Cejka, Kamila Polakova, Hana Brozova, Zoltan Szabo, Evzen Ruzicka, Robert Jech
J Appl Biomed 17:157-166, 2019 | DOI: 10.32725/jab.2019.014 
Exploration of motor cortex activity is essential to understanding the pathophysiology in Parkinson's Disease (PD), but only simple motor tasks can be investigated using a fMRI or PET. We aim to investigate the cortical activity of PD patients during a complex motor task (gait) to verify the impact of deep brain stimulation in the subthalamic nucleus (DBS-STN) by using Near-Infrared-Spectroscopy (NIRS). NIRS is a neuroimaging method of brain cortical activity using low-energy optical radiation to detect local changes in (de)oxyhemoglobin concentration. We used a multichannel portable NIRS during finger tapping (FT) and gait. To determine the signal...
Prediction of semen quality using artificial neural network
Anna Badura, Urszula Marzec-Wróblewska, Piotr Kamiński, Paweł Łakota, Grzegorz Ludwikowski, Marek Szymański, Karolina Wasilow, Andżelika Lorenc, Adam Buciński
J Appl Biomed 17:167-174, 2019 | DOI: 10.32725/jab.2019.015
Examination of semen characteristics is routinely performed for fertility status investigation of the male partner of an infertile couple as well as for evaluation of the sperm donor candidate. A useful tool for preliminary assessment of semen characteristics might be an artificial neural network. Thus, the aim of the present study was to construct an artificial neural network, which could be used for predicting the result of semen analysis based on the basic questionnaire data. On the basis of eleven survey questions two models of artificial neural networks to predict semen parameters were developed. The first model aims to predict the overall performance...
Correlation of adenosine deaminase operating under nitro-oxidative stress with tumor and vascularization in patients with advanced gallbladder carcinoma
Nabila Tounsi, Bahia Djerdjouri, Chafik Bouzid, Kamel Bentabak
J Appl Biomed 17:175-183, 2019 | DOI: 10.32725/jab.2019.016
This study investigates serum redox status and adenosine catabolism markers in relation to tumor and angiogenesis, in patients with gallbladder carcinoma (GBC). The level of adenosine deaminase (ADA) and xanthine oxidase (XO) activities, nitrites (NO2-), glutathione (GSH) and malondialdehyde (MDA) were measured in sera of 40 GBC patients and 40 healthy donors. In parallel, 15 tumors at TNM stage IV were scored for CD34 expression and microvessel density (MVD). The results showed that XO and ADA activities, nitrites and MDA levels enhanced by 1.26 (p < 0.01), 2.69, 2.0, and 3.2-fold (p < 0.001), respectively, while those...
Positive association between a polymorphic locus near the LBX1 gene and predisposition of idiopathic scoliosis in Southeastern European population
Svetla Nikolova, Milka Dikova, Dobrin Dikov, Assen Djerov, Alexey Savov, Ivo Kremensky, Alexandre Loukanov
J Appl Biomed 17:184-189, 2019 | DOI: 10.32725/jab.2019.011
Idiopathic scoliosis (IS) is a common medical condition in children, characterized by three-dimensional spinal curve and strong evidence of genetic predisposition. The purpose of the present case-control study is to examine the association between the polymorphic variant rs11190870 (T/C), near the LBX1 gene, and IS predisposition in distinct subgroups based on age at onset, family history and gender. A total of 127 IS patients and 254 unrelated controls of Southeastern European descent were recruited. The genotyping was carried out by TaqMan real-time amplification technology. The results were analyzed by the Pearson's Chi-squared Test and the...
Beneficial effects of Stevioside on AGEs, blood glucose, lipid profile and renal status in streptozotocin-induced diabetic rats
Urmila Aswar, Vinayak Gogawale, Pankaj Miniyar, Yugendra Patil
J Appl Biomed 17:190-197, 2019 | DOI: 10.32725/jab.2019.013
The advanced glycated end products (AGEs) are formed in the diabetic patients; it is a major cause of macrovascular and microvascular complications in diabetes. Clinically there is no treatment available for the AGEs. Stveoside (Stv), a sweetener has potent anti-diabetic and anti-oxidant activity. Hence, we investigated its use in prevention of AGEs formation using in vitro and in vivo models. Diabetes was induced by streptozotocin (STZ). These rats were kept without treatment till blood HbA1c was markedly increased. They were then divided into 5 groups and treated orally with vehicle or Metformin (MET) or Stv respectively for 28 days....
Review Article
Identification and applications of neuroactive silk proteins: a narrative review
Ahad Banagozar Mohammadi, Saeed Sadigh-Eteghad, Mohammadali Torbati, Seyyed Mohammad Bagher Fazljou, Seyed Mehdi Vatandoust, Samad EJ Golzari, Fereshteh Farajdokht, Javad Mahmoudi
J Appl Biomed 17:147-156, 2019 | DOI: 10.32725/jab.2019.012
In traditional medicine, natural silk is regarded as a cognitive enhancer and a cure for ameliorating the symptoms of heart disease, atherosclerosis, and metabolic disorders. In this review, general characteristics of both silk proteins, fibroin and sericin, extracted from silkworm Bombyx mori and their potential use in the neuronal disorders was discussed. Evidence shows that silk proteins exhibit neuroprotective effects in models of neurotoxicity. The antioxidant, neuroprotective, and acetylcholinesterase inhibitory mechanisms of silk proteins could prove promising in the treatment of neurodegenerative diseases. Owing to their excellent neurocompatibility...