J Appl Biomed 17:157-166, 2019 | DOI: 10.32725/jab.2019.014

Reshaping cortical activity with subthalamic stimulation in Parkinson's disease during finger tapping and gait mapped by near infrared spectroscopy

Ondrej Klempir1,*, Radim Krupicka1, Jan Mehnert3,4, Vaclav Cejka1,2, Kamila Polakova2, Hana Brozova2, Zoltan Szabo1, Evzen Ruzicka2, Robert Jech2
1 Czech Technical University in Prague, Faculty of Biomedical Engineering, Department of Biomedical Informatics, Kladno, Czech Republic
2 Charles University, First Faculty of Medicine and General University Hospital, Department of Neurology, Prague, Czech Republic
3 University Medical Center Eppendorf, Department of Systems Neuroscience, Hamburg, Germany
4 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

Exploration of motor cortex activity is essential to understanding the pathophysiology in Parkinson's Disease (PD), but only simple motor tasks can be investigated using a fMRI or PET. We aim to investigate the cortical activity of PD patients during a complex motor task (gait) to verify the impact of deep brain stimulation in the subthalamic nucleus (DBS-STN) by using Near-Infrared-Spectroscopy (NIRS). NIRS is a neuroimaging method of brain cortical activity using low-energy optical radiation to detect local changes in (de)oxyhemoglobin concentration. We used a multichannel portable NIRS during finger tapping (FT) and gait. To determine the signal activity, our methodology consisted of a pre-processing phase for the raw signal, followed by statistical analysis based on a general linear model. Processed recordings from 9 patients were statistically compared between the on and off states of DBS-STN. DBS-STN led to an increased activity in the contralateral motor cortex areas during FT. During gait, we observed a concentration of activity towards the cortex central area in the "stimulation-on" state. Our study shows how NIRS can be used to detect functional changes in the cortex of patients with PD with DBS-STN and indicates its future use for applications unsuited for PET and a fMRI.

Keywords: Deep brain stimulation; Gait; Near infrared spectroscopy; Neuroinformatics; Parkinson's disease; Subthalamic nucleus
Grants and funding:

This work was supported by the Czech Science foundation GACR 16-13323S; the Czech Ministry of Health (AZV Grant no. 16-28119a and no. 17-32318a).

Conflicts of interest:

The authors declare no conflict of interests in this article

Received: May 30, 2018; Accepted: August 19, 2019; Prepublished online: September 11, 2019; Published: September 18, 2019  Show citation

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Klempir O, Krupicka R, Mehnert J, Cejka V, Polakova K, Brozova H, et al.. Reshaping cortical activity with subthalamic stimulation in Parkinson's disease during finger tapping and gait mapped by near infrared spectroscopy. J Appl Biomed. 2019;17(3):157-166. doi: 10.32725/jab.2019.014. PubMed PMID: 34907697.
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