J Appl Biomed 17:218-224, 2019 | DOI: 10.32725/jab.2019.020

Chokeberry juice supplementation in type 2 diabetic patients - impact on health status

Milica Milutinović1, Radmila Veličković Radovanović2,3, Katarina Šavikin4, Saša Radenković5,6, Marjan Arvandi7, Milica Pešić5,6, Milica Kostić1, Bojana Miladinović1, Suzana Branković8, Dušanka Kitić1 *
1 University of Niš, Faculty of Medicine, Department of Pharmacy, Niš, Serbia
2 University of Niš, Faculty of Medicine, Department of Pharmacology, Niš, Serbia
3 Clinical Center Niš, Clinic of Nephrology, Niš, Serbia
4 Institute for Medicinal Plants Research "Dr. Josif Pančić", Belgrade, Serbia
5 University of Niš, Faculty of Medicine, Department of Internal Medicine, Niš, Serbia
6 Clinical Center Niš, Clinic of Endocrinology, Diabetes and Metabolic Disorders, Niš, Serbia
7 Institute of Public Health, Medical Decision Making, and Health Technology Assessment, UMIT, Hall in Tirol, Austria
8 University of Niš, Faculty of Medicine, Department of Physiology, Niš, Serbia

Recent literature evidence indicates the potential use of chokeberry preparations in the prevention and treatment of some chronic noncommunicable diseases. The aim of the present study was to evaluate the effects of the three months oral chokeberry juice supplementation in type 2 diabetic patients, as well as its influence on hematological parameters and certain parameters of the renal dysfunction. The study was designed as an open-label trial, which included 35 patients who have received the herbal supplement, polyphenol-rich chokeberry juice (150 ml/day, three times a day for 50 ml), in addition to their standard therapy. Chokeberry juice as a rich source of polyphenol compounds could be an effective preventive and therapeutic agent in diabetes mellitus type 2. Hematological and biochemical parameters were measured at baseline, after 3 months with the chokeberry juice supplementation and after the next 3 months without the chokeberry juice supplementation (follow-up period). Significant difference was noticed in the levels of LDL-cholesterol, glycated hemoglobin and serum creatinine (p < 0.05), as well as in the levels of some hematological parameters, such as white blood cell and lymphocyte count (p < 0.01), hematocrit, blood hemoglobin, mean corpuscular volume, hemoglobin and hemoglobin concentration and red blood cell count (p < 0.05). The daily consumption of the chokeberry juice could improve the health status in patients with type 2 diabetes mellitus, in combination with their standard therapy.

Keywords: Aronia melanocarpa; Diabetes mellitus type 2; Hematological parameters; Juice; Renal dysfunction
Grants and funding:

This study was supported by the Serbian Ministry of Education, Science and Technological Development (Grant no. III 46013 and III 41018) and by the Internal Project of the Faculty of Medicine, University of Nis, Serbia (No. 25). The authors are thankful to dr Aleksandra Ignjatovic, Faculty of Medicine, University of Nis for her expertise in statistical data processing and Mr. Aleksandar Jovanovic for his expertise in English.

Conflicts of interest:

The authors have no conflict of interests to declare.

Received: November 6, 2018; Revised: November 4, 2019; Accepted: November 4, 2019; Prepublished online: November 13, 2019; Published: December 13, 2019  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Milutinović M, Veličković Radovanović R, Šavikin K, Radenković S, Arvandi M, Pešić M, et al.. Chokeberry juice supplementation in type 2 diabetic patients - impact on health status. J Appl Biomed. 2019;17(4):218-224. doi: 10.32725/jab.2019.020. PubMed PMID: 34907720.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Asmat U, Abad K, Ismail K (2016). Diabetes mellitus and oxidative stress - A concise review. Saudi Pharm J 24(5): 547-553. DOI: 10.1016/j.jsps.2015.03.013. Go to original source... Go to PubMed...
    2. Badescu M, Badulescu O, Badescu L, Ciocoiu M (2015). Sambucus nigra and Aronia melanocarpa extracts on immune system disorders within diabetes mellitus. Pharm Biol 53(4): 533-539. DOI: 10.3109/13880209.2014.931441. Go to original source... Go to PubMed...
    3. Banjari I, Misir A, Šavikin K, Jokic S, Molnar M, De Zoysa HK, et al. (2017). Antidiabetic effects of Aronia melanocarpa and itsother therapeutic properties. Front Nutr 4: 53. DOI: 10.3389/fnut.2017.00053. Go to original source... Go to PubMed...
    4. Bi Y, Wang T, Xu M, Xu Y, Li M, Lu J, et al. (2012). Advanced research on risk factors of type 2 diabetes. Diabetes Metab Res Rev 28(Suppl. 2.): 32-39. DOI: 10.1002/dmrr.2352. Go to original source... Go to PubMed...
    5. Bloom DE, Cafiero ET, Jané-Llopis E, Abrahams-Gessel S, Bloom LR, Fathima S, et al. (2011). The global economic burden of noncommunicable diseases. Geneva: World Economic Forum. Report No.: 080911.
    6. Borowska S, Brzóska MM (2016). Chokeberries (Aronia melanocarpa) and their products as a possible means for the prevention and treatment of noncommunicable diseases and unfavorable health effects due to exposure to xenobiotics. Compr Rev Food Sci F 15(6): 982-1017. DOI: 10.1111/1541-4337.12221. Go to original source... Go to PubMed...
    7. Braunlich M, Slimestad R, Wangensteen H, Brede C, Malterud KE, Barsett H (2013). Extracts, anthocyanins and procyanidins from Aronia melanocarpa as radical scavengers and enzyme inhibitors. Nutrients 5(3): 663-678. DOI: 10.3390/nu5030663. Go to original source... Go to PubMed...
    8. Broncel M, Kozirog M, Duchnowicz P, Koter-Michalak M, Sikora J, Chojnowska-Jezierska J (2010). Aronia melanocarpa extract reduces blood pressure, serum endothelin, lipid, and oxidative stress marker levels in patients with metabolic syndrome. Med Sci Monit 16(1): CR28-34.
    9. Calvo SM, Mehrotra A, Beelman BR, Nadkarni G, Wang L, Cai W, et al. (2016). A retrospective study in adults with metabolic syndrome: diabetic risk factor response to daily consumption of Agaricus bisporus (White Button Mushrooms). Plant Food Hum Nutr 71(3): 245-251. DOI: 10.1007/s11130-016-0552-7. Go to original source... Go to PubMed...
    10. Cardillo C, Campia U, Bryant MB, Panza JA (2002). Increased activity of endogenous endothelin in patients with type II diabetes mellitus. Circulation 106(14): 1783-1787. DOI: 10.1161/01.cir.0000032260.01569.64. Go to original source... Go to PubMed...
    11. Chung FM, Tsai JC, Chang DM, Shin SJ, Lee YJ (2005). Peripheral total and differential leukocyte count in diabetic nephropathy. Diabetes Care 28(7): 1710-1717. DOI: 10.2337/diacare.28.7.1710. Go to original source... Go to PubMed...
    12. Cohen MP (1998). Nonenzymatic glycation: a central mechanism in diabetic microvasculopathy? J Diabet Complications 2(4): 214-217. DOI: 10.1016/s0891-6632(88)80012-6. Go to original source... Go to PubMed...
    13. Council of Europe, European Pharmacopoeia Commission (2007). European Pharmacopoeia 6.0. 6th ed. Strasbourg: Council of Europe, pp. 1307-1308.
    14. Edirisinghe I, Burton-Freeman B (2016). Anti-diabetic actions of Berry polyphenols - Review on proposed mechanisms of action. J Berry Res 6(2): 237-250. DOI: 10.3233/JBR-160137. Go to original source...
    15. Ford ES (2002). Leukocyte count, erythrocyte sedimentation rate, and diabetes incidence in a national sample of US adults. Am J Epidemiol 155(1): 57-64. DOI: 10.1093/aje/155.1.57. Go to original source... Go to PubMed...
    16. Hamdy O, Ledbury S, Mullooly C, Jarema C, Porter S, Ovalle K, et al. (2003). Lifestyle modification improves endothelial function in obese subjects with the insulin resistance syndrome. Diabetes Care 26(7): 2119-2125. DOI: 10.2337/diacare.26.7.2119. Go to original source... Go to PubMed...
    17. Hanley AJ, Retnakaran R, Qi Y, Gerstein HC, Perkins B, Raboud J, et al. (2009). Association of hematological parameters with insulin resistance and β-Cell dysfunction in nondiabetic subjects. J. Clin Endocrinol Metab 94(10): 3824-3832. DOI: 10.1210/jc.2009-0719. Go to original source... Go to PubMed...
    18. IDF Clinical Guidelines Task Force (2006). Global guideline for type 2 diabetes: recommendations for standard, comprehensive, and minimal care. Diabet Med 23(6): 579-593. DOI: 10.1111/j.1464-5491.2006.01918.x. Go to original source... Go to PubMed...
    19. Kardum N, Milovanović B, Šavikin K, Zdunić G, Mutavdžin S, Gligorijević T, Spasić S (2015). Beneficial effects of polyphenol-rich chokeberry juice consumption on blood pressure level and lipid status in hypertensive subjects. J Med Food 18(11): 1231-1238. DOI: 10.1089/jmf.2014.0171. Go to original source... Go to PubMed...
    20. Kardum N, Petrović-Oggiano G, Takic M, Glibetić N, Zec M, Debeljak-Martacic J, Konić-Ristić A (2014). Effects of glucomannan-enriched, aronia juice-based supplement on cellular antioxidant enzymes and membrane lipid status in subjects with abdominal obesity. Sci World J 2014: 869250. DOI: 10.1155/2014/869250. Go to original source... Go to PubMed...
    21. King P, Peacock I, Donnelly R (1999). The UK Prospective Diabetes Study (UKPDS): clinical and therapeutic implicationsfor type 2 diabetes. Br J Clin Pharmacol 48(5): 643-648. DOI: 10.1046/j.1365-2125.1999.00092.x. Go to original source... Go to PubMed...
    22. Kokotkiewicz A, Jaremicz Z, Luczkiewicz M (2010). Aronia plants: a review of traditional use, biological activities, and perspectives for modern medicine. J Med Food 13(2): 255-269. DOI: 10.1089/jmf.2009.0062. Go to original source... Go to PubMed...
    23. Krentz AJ, Bailey CJ (2005). Oral antidiabetic agents: current role in type 2 diabetes mellitus. Drugs 65(3): 385-411. DOI: 10.2165/00003495-200565030-00005. Go to original source... Go to PubMed...
    24. Kris-Etherton PM, Hecker KD, Bonanome A, Coval SM, Binkoski EA, Hilpert KF, et al. (2002). Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Am J Med 113(Suppl 9B): 71-88. DOI: 10.1016/s0002-9343(01)00995-0. Go to original source... Go to PubMed...
    25. Kulling SE, Rawel HM (2008). Chokeberry (Aronia melanocarpa) - a review on the characteristic components and potential health effects. Planta Med 74(13): 1625-1634. DOI: 10.1055/s-0028-1088306. Go to original source... Go to PubMed...
    26. Maitre J, Guinhouya B, Darrieutort N, Paillard T (2017). Physical education in a thermal spa resort to maintain an active lifestyle at home: a one-year self-controlled follow-up pilot study. Evid Based Complement Alternat Med 2017(8): ID 1058419. DOI: 10.1155/2017/1058419. Go to original source... Go to PubMed...
    27. Meng S, Cao J, Feng Q, Peng J, Hu Y (2013). Roles of chlorogenic acid on regulating glucose and lipids metabolism: a review. Evid Based Complement Alternat Med 2013: 801457. DOI: 10.1155/2013/801457. Go to original source... Go to PubMed...
    28. Narayan KM, Gregg EW, Fagot-Campagna A, Engelgau MM, Vinicor F (2000). Diabetes - a common, growing, serious, costly, and potentially preventable public health problem. Diabetes Res Clin Pract 50(Suppl. 2): S77-S84. DOI: 10.1016/s0168-8227(00)00183-2. Go to original source... Go to PubMed...
    29. Naruszewicz M, Daniewski M, Łaniewska I, Pikto-Pietkiewicz W, Millo B, Zapolska-Downar D (2003). Effect of anthocyanins from chokeberry (Aronia melanocarpa) on blood pressure, inflammatory mediators and cell adhesion molecules in patients with a history of myocardial infarction (MI). Atheroscler Suppl 4(2): 143. DOI: 10.1016/S1567-5688(03)90615-5. Go to original source...
    30. Naruszewicz M, Laniewska I, Millo B, Dłuzniewski M (2007). Combination therapy of statin with flavonoids rich extract from chokeberry fruits enhanced reduction in cardiovascular risk markers in patients after myocardial infarction (MI). Atherosclerosis 194(2): e179-e84. DOI: 10.1016/j.atherosclerosis.2006.12.032. Go to original source... Go to PubMed...
    31. Olivares R, Ducimetiere P, Claude JR (1993). Monocyte count: a risk factor for coronary heart disease. Am J Epidemiol 137(1): 49-53. DOI: 10.1093/oxfordjournals.aje.a116601. Go to original source... Go to PubMed...
    32. Prentice RL, Szatrowski TP, Fujikura T, Kato H, Mason MW, Hamilton HH (1982). Leukocyte counts and coronary heart disease in a Japanese cohort. Am J Epidemiol 116(3): 496-509. DOI: 10.1093/oxfordjournals.aje.a113434. Go to original source... Go to PubMed...
    33. Qin B, Anderson RA (2012). An extract of chokeberry attenuates weight gain and modulates insulin, adipogenic and inflammatory signalling pathways in epididymal adipose tissue of rats fed a fructose-rich diet. Brit J Nutr 108(4): 581-587. DOI: 10.1017/S000711451100599X. Go to original source... Go to PubMed...
    34. Rugina D, Diaconeasa Z, Coman C, Bunea A, Socaciu C, Pintea A (2015). Chokeberry anthocyanin extract as pancreatic β-cell protectors in two models of induced oxidative stress. Oxid Med Cell Longev 2015: 429075. DOI: 10.1155/2015/429075. Go to original source... Go to PubMed...
    35. Rugina D, Sconta Z, Pintea A, Bunea A, Socaciu C (2011). Protective effect of chokeberry anthocyanin-rich fraction at nanomolar concentrations against oxidative stress induced by high doses of glucose in pancreatic β-cells. Bulletin UASVM Cluj Napoca 68(1): 313-319. DOI: 10.15835/buasvmcn-vm:1:68:6792. Go to original source...
    36. Shin JH, Jung JH (2016). Reduction of adipogenesis by chokeberry (Aronia melanocarpa) extract in 3T3-L1 preadipocytes. J Food Nutr Res 4: 210-215. DOI: 10.12691/jfnr-4-4-3. Go to original source...
    37. Sikora J, Broncel M, Markowicz M, Chałubinski M, Wojdan K, Mikiciuk-Olasik E (2012). Short-term supplementation with Aronia melanocarpa extract improves platelet aggregation, clotting, and fibrinolysis in patients with metabolic syndrome. Eur J Nutr 51(5): 549-556. DOI: 10.1007/s00394-011-0238-8. Go to original source... Go to PubMed...
    38. Simeonov SB, Botushanov NP, Karahanian EB, Pavlova MB, Husianitis HK, Troev DM (2002). Effects of Aronia melanocarpa juice as part of the dietary regimen in patients with diabetes mellitus. Folia Med (Plovdiv) 44(3): 20-23. Go to PubMed...
    39. Skoczynska A, Jedrychowska I, Poreba R, Affelska-Jercha A, Turczyn B, Wojakowska A, Andrzejak R (2007). Influence of chokeberry juice on arterial blood pressure and lipid parameters in men with mild hypercholesterolemia. Pharmacol Rep 59(1): 177-182.
    40. Tong PC, Lee KF, So WY, Ng MH, Chan WB, Lo MK, et al. (2004). White blood cell count is associated with macro and microvascular complications in Chinese patients with type 2 diabetes. Diabetes Care 27(1): 216-222. DOI: 10.2337/diacare.27.1.216. Go to original source... Go to PubMed...
    41. Umayahara Y, Fujita Y, Watanabe H, Kasai N, Fujiki N, Hatazaki M, Koga M (2017). Association of glycated albumin to HbA1c ratio with diabetic retinopathy but not diabetic nephropathy in patients with type 2 diabetes. Clin Biochem 50(6): 270-273. DOI: 10.1016/j.clinbiochem.2016.11.032. Go to original source... Go to PubMed...
    42. Valcheva-Kuzmanova S, Kuzmanov K, Tancheva S, Belcheva A (2007a). Hypoglycemic and hypolipidemic effects of Aronia melanocarpa fruit juice in streptozotocin-induced diabetic rats. Methods Find Exp Clin Pharmacol 29(2): 101-105. DOI: 10.1358/mf.2007.29.2.1075349. Go to original source... Go to PubMed...
    43. Valcheva-Kuzmanova S, Kuzmanov K, Mihova V, Krasnaliev I, Borisova P, Belcheva A (2007b). Antihyperlipidemic effect of Aronia melanocarpa fruit juice in rats fed a high-cholesterol diet. Plant Food Hum Nutr 62(1): 19-24. DOI: 10.1007/s11130-006-0036-2. Go to original source... Go to PubMed...
    44. Waterman P, Mole S (1994). Analysis of phenolic plant metabolites. Oxford: Blackwell Scientific Publication, pp.16.
    45. Wedick NM, Pan A, Cassidy A, Rimm EB, Sampson L, Rosner B, et al. (2012). Dietary flavonoid intakes and risk of type 2 diabetes in US men and women. Am J Clin Nutr 95(4): 925-933. DOI: 10.3945/ajcn.111.028894. Go to original source... Go to PubMed...
    46. WHO (2016). Global status reports on noncommunicable diseases 2014. Geneva: WHO Press.
    47. Yamane T, Kozuka M, Wada-Yoneta M, Sakamoto T, Nakagaki T, Nakano Y, Ohkubo I (2017). Aronia juice suppresses the elevation of postprandial blood glucose levels in adult healthy Japanese. Clin Nutr Exp 12: 20-26. DOI: 10.1016/j.yclnex.2017.01.002. Go to original source...
    48. Zhu W, Jia Q, Wang Y, Zhang Y, Xia M (2012). The anthocyanin cyanidin-3-O-β-glucoside, a flavonoid, increases hepatic glutathione synthesis and protects hepatocytes against reactive oxygen species during hyperglycemia: involvement of cAMP-PKA-dependent signalling pathway. Free Radic Biol Med 52(2): 314-327. DOI: 10.1016/j.freeradbiomed.2011.10.483. Go to original source... Go to PubMed...

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0), which permits non-comercial use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.


    Return to the content