J Appl Biomed 18:54-60, 2020 | DOI: 10.32725/jab.2020.007

Circulating levels of selected adipokines in women with gestational diabetes and type 2 diabetes

David Karasek1 *,Veronika Kubickova 2, Ondrej Krystynik1, Dominika Goldmannova1, Lubica Cibickova1, Jan Schovanek1
1 University Hospital and Palacky University, Faculty of Medicine and Dentistry, Third Department of Internal Medicine - Nephrology, Rheumatology and Endocrinology, Olomouc, Czech Republic
2 University Hospital, Department of Clinical Biochemistry, Olomouc, Czech Republic

Backgrounds: Adiponectin, adipocyte-fatty acid binding protein (A-FABP), and Wnt1 inducible signaling pathway protein-1 (WISP-1) are adipokines closely associated with insulin resistance. The aim of the study was to compare their levels in women with gestational diabetes (GDM), type 2 diabetes mellitus (T2DM) and healthy controls and determine their relation to metabolic parameters.

Methods: Women with GDM, T2DM and healthy women were included in this cross-sectional study. In addition to adipokines, anthropometric, lipid parameters, markers of insulin resistance and glucose control were assessed in all participants.

Results: Compared to healthy controls (n = 35) significantly lower levels of adiponectin were detected in women with GDM (n = 50), whereas in women with T2DM (n = 50) higher levels of A-FABP and WISP-1 and lower levels of adiponectin were found. Women with T2DM had also lower levels of adiponectin and higher levels of A-FABP compared to women with GDM. A-FABP and adiponectin were independently associated with levels of triglycerides, HDL-cholesterol and C-peptide insulin resistance index. WISP-1 correlated only with waist circumference.

Conclusions: Adverse adipokines production reflecting dysfunctional fat tissue is less presented in women with GDM than in women with T2DM, but more expressed compared to healthy women.

Keywords: Adipocyte-fatty acid binding protein; Adiponectin; Gestational diabetes; Insulin resistance; Type 2 diabetes; Wnt1 inducible signaling pathway protein-1
Grants and funding:

Financial support of this study was provided by Czech health research council (AZV NV18- 01-00139) and University Hospital Olomouc – MH CZ DRO (FNOl, 00098892). Funding sources were not involved in the study design, in the collection, analysis and interpretation of data, in the writing of the report, and in the decision to submit the article for publication.

Conflicts of interest:

The authors have no conflict of interests to declare.

Received: July 29, 2019; Revised: March 29, 2020; Accepted: March 30, 2020; Prepublished online: May 18, 2020; Published: August 27, 2020  Show citation

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Karasek D, Krystynik O, Goldmannova D, Cibickova L, Schovanek J. Circulating levels of selected adipokines in women with gestational diabetes and type 2 diabetes. J Appl Biomed. 2020;18(2-3):54-60. doi: 10.32725/jab.2020.007. PubMed PMID: 34907726.
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