Journal of Applied Biomedicine, 2020 (vol. 18), issue 2-3
Original Research Article
Application of a neural interface for restoration of leg movements: Intra-spinal stimulation using the brain electrical activity in spinally injured rabbits
Mohamad Amin Younessi Heravi, Keivan Maghooli, Fereidoun Nowshiravan Rahatabad, Ramin Rezaee
J Appl Biomed 18:33-40, 2020 | DOI: 10.32725/jab.2020.009 
This study aimed to design a neural interface that extracts movement commands from the brain to generate appropriate intra-spinal stimulation to restore leg movement. This study comprised four steps: (1) Recording electrocorticographic (ECoG) signals and corresponding leg movements in different trials. (2) Partial laminectomy to induce spinal cord injury (SCI) and detect motor modules in the spinal cord. (3) Delivering appropriate intra-spinal stimulation to the motor modules for restoration of the movements to those documented before SCI. (4) Development of a neural interface created by sparse linear regression (SLiR) model to detect movement commands...
Clinical comparison of platelet-rich plasma injection and daily celecoxib administration in the treatment of early knee osteoarthritis: A randomized clinical trial
Rubén Reyes-Sosa, Agustin Lugo-Radillo, Lizzet Cruz-Santiago, Celia Rubí García-Cruz, Oliver Mendoza-Cano
J Appl Biomed 18:41-45, 2020 | DOI: 10.32725/jab.2020.012
Background: Oral and topical nonsteroidal anti-inflammatory drugs (NSAIDs), analgesics and intra-articular corticosteroid injections are the recommended first line of treatment for knee osteoarthritis (OA); however, they have serious side effects. Platelet-rich plasma (PRP) has been posited as an effective and safer alternative treatment for knee OA. Hitherto, there is only one study comparing the effectiveness of PRP against an NSAID. Aim of the study: The aim of this study was to determine the effectiveness of PRP against celecoxib in the treatment of early knee OA. Methods: 60 patients with knee OA grade II and III were randomly alocated in two...
Moonlight human ribosomal protein L13a downregulation is associated with p53 and HER2/neu expression in breast cancer
Ghader Molavi, Nasser Samadi, Shahriar Hashemzadeh, Monireh Halimi, Elaheh Zadeh Hosseingholi
J Appl Biomed 18:46-53, 2020 | DOI: 10.32725/jab.2020.008
Breast cancer is the most common malignancy among females worldwide. Recent studies have shown extra-ribosomal roles of the moonlight ribosomal proteins in the development of human cancers. Accurate quantification of the gene expression level is based on the selection of the reference genes whose expression is independent of cancer properties and patient's characteristics. The aim of this study was the evaluation of the expression level of a previously proposed ribosomal protein as moonlight, L13a (RPL13A), in breast cancer samples and their adjacent tissues. Its association with genes of known roles in developing cancers was also investigated. Traditionally...
Circulating levels of selected adipokines in women with gestational diabetes and type 2 diabetes
David Karasek, Ondrej Krystynik, Dominika Goldmannova, Lubica Cibickova, Jan Schovanek
J Appl Biomed 18:54-60, 2020 | DOI: 10.32725/jab.2020.007
Backgrounds: Adiponectin, adipocyte-fatty acid binding protein (A-FABP), and Wnt1 inducible signaling pathway protein-1 (WISP-1) are adipokines closely associated with insulin resistance. The aim of the study was to compare their levels in women with gestational diabetes (GDM), type 2 diabetes mellitus (T2DM) and healthy controls and determine their relation to metabolic parameters. Methods: Women with GDM, T2DM and healthy women were included in this cross-sectional study. In addition to adipokines, anthropometric, lipid parameters, markers of insulin resistance and glucose control were assessed in all participants. Results: Compared to healthy controls...
Association of FGF19, FGF21 and FGF23 with carbohydrate metabolism parameters and insulin resistance in patients with chronic kidney disease
Małgorzata Marchelek-Myśliwiec, Violetta Dziedziejko, Katarzyna Dołęgowka, Andrzej Pawlik, Krzysztof Safranow, Joanna Stępniewska, Magda Wiśniewska, Jolanta Małyszko, Kazimierz Ciechanowski
J Appl Biomed 18:61-69, 2020 | DOI: 10.32725/jab.2020.005
Insulin resistance (IR) is characterised by increased gluconeogenesis in the liver and the resistance of peripheral receptors to insulin. Several factors, including IR, type 2 diabetes, new-onset diabetes after transplant (NODAT) and secondary parathyroidism, are related to chronic kidney disease (CKD). These factors are associated with higher mortality due to the increased risk of cardiovascular complications. Many factors have been identified as potential markers of IR in CKD. These factors include fibroblast growth factors (FGFs), a subfamily of endocrine polypeptides. In this study, we examined the association of FGF19, FGF21 and FGF23 with selected...
Cichorium intybus attenuates Streptozotocin-induced pancreatic β-cell damage by inhibiting NF-κB activation and oxidative stress
Ramya Devi KT *, Nageswaran Sivalingam
J Appl Biomed 18:70-79, 2020 | DOI: 10.32725/jab.2020.010
The aqueous extract of Cichorium intybus (CIE) leaves have shown the properties of protecting against pancreatic β-cell damage by streptozotocin (STZ), but the molecular mechanisms of its protection are not completely elucidated yet. Our current study focuses on elucidating the mechanisms of these preventive effects of CIE in MIN6 cells and an in-vivo model of Wistar rats. CIE offers protection against STZ in MIN6 cells by reducing the pro-oxidants and increasing the activity of the antioxidant enzymes. In vitro results also indicated that CIE inhibited cytotoxicity, reduced Reactive oxygen species (ROS), maintained glucose-stimulated...
A study of the hepatoprotective effect of Plantago psyllium L. seed extract against Carbon tetrachloride induced hepatic injury in rats
Mekky M Abouzied, Shaymaa M Mahmoud, Ahmed Wahid, Amr E Ahmed, Ahmed M Okasha, Hanan A Soliman, Sultan S Al Thagfan, Eman Z Attia
J Appl Biomed 18:80-86, 2020 | DOI: 10.32725/jab.2020.006
Background: The liver is the main metabolic organ involved in disposal and detoxification of various molecules. Plantago psyllium L. seed has been reported to exert positive effects in some pathological conditions. The current study aims to assess the hepatoprotective effect of Plantago psyllium L. seed extract against carbon tetrachloride-induced hepatotoxicity. Methods: Male albino Wistar rats were randomly divided into five groups of 10 rats each. Hepatotoxicity was induced by orally administered carbon tetrachloride (CCl4) for nine weeks with or without the different treatments which were utilized daily for the whole nine weeks. Serum...
A biochemical approach to the anti-inflammatory, antioxidant and antiapoptotic potential of beta-carotene as a protective agent against bromobenzene-induced hepatotoxicity in female Wistar albino rats
Priya Josson Akkara, Evan Prince Sabina
J Appl Biomed 18:87-95, 2020 | DOI: 10.32725/jab.2020.011
Bromobenzene is a compound which has contributed much in understanding the mechanisms involved in xenobiotic hepatotoxicity induced by drugs and environment pollutants. In the present study, the protective and ameliorative effect of beta-carotene was investigated against bromobenzene-induced hepatotoxicity and compared with silymarin, a standard hepatoprotective reference drug. Beta-carotene (10 mg/kg b.w. p.o.) was administered to the rats for 9 days before intragastric intubation of bromobenzene (10 mmol/kg b.w.). Liver marker enzymes (aspartate transaminase, alanine transaminase and alkaline phosphatase), total protein content, bilirubin,...