J Appl Biomed 18:115-125, 2020 | DOI: 10.32725/jab.2020.015

Rosuvastatin, Perindopril and Ezetimibe loaded instant release buccal films: Development and in vitro characterization

Sobia Anwar1, Muhammad Zaman1,2, Maria Abdul Ghafoor Raja3, Asif Mahmood1, Muhammad Wahab Amjad3,*
1 The University of Lahore, Faculty of Pharmacy, Department of Pharmaceutics, Lahore, Pakistan
2 University of Central Punjab, Faculty of Pharmacy, Department of Pharmaceutics, Lahore, Pakistan
3 Northern Border University, Faculty of Pharmacy, Department of Pharmaceutics, Rafha, Kingdom of Saudi Arabia

Background: Rosuvastatin Calcium and Ezetimibe are used to control cholesterol level while Perindopril Erbumine is used to treat hypertension. Hepatic metabolism reduces the therapeutic effect of these drugs.

Objective: Instant release buccal films (IRBFs) could possibly be a solution to this issue. The objective of the study was to formulate IRBFs of Rosuvastatin Calcium, Perindopril Erbumine and Ezetimibe using solvent casting technique.

Methods: Polymers used to prepare IRBFs included hydroxypropyl methylcellulose (HPMC E5), PEG 400 (as plasticizer) and Tween 80 (as surfactant). Solvent casting technique was used to fabricate the films, followed by their in-vitro analysis including high performance liquid chromatography (HPLC), X-ray diffraction (XRD), fourier transform infrared evaluation (FTIR), In-vitro dissolution, In-vitro disintegration, stability tests, scanning electron microscopy (SEM), folding fortitude, thickness evaluation, surface pH, tensile strength, weight variation and percentage moisture content.

Results: Optical microscopy as well as SEM analysis displayed that the surfaces of IRBFs were smooth with uniform mixing of ingredients. IRBFs disintegrated within 15 seconds while on dissolution they exhibited instant drug release i.e. 100% release in 2 minutes.

Conclusions: The results show promising potential of IRBFs in drug delivery.

Keywords: Buccal films; Ezetimibe; Instant release; Perindopril; Rosuvastatin
Conflicts of interest:

The authors have no conflict of interests to declare.

Received: May 16, 2020; Revised: September 11, 2020; Accepted: October 4, 2020; Prepublished online: October 27, 2020; Published: December 14, 2020  Show citation

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Anwar S, Zaman M, Raja MAG, Mahmood A, Amjad MW. Rosuvastatin, Perindopril and Ezetimibe loaded instant release buccal films: Development and in vitro characterization. J Appl Biomed. 2020;18(4):115-125. doi: 10.32725/jab.2020.015. PubMed PMID: 34907764.
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