J Appl Biomed 20:141-145, 2022 | DOI: 10.32725/jab.2022.016

Assessment of plasma catecholamines in patients with dysmetabolic iron overload syndrome

Hany William Z. Hanna1 *, Heba N Baz1, Lika'a Fasih Y. Al-Kzayer2, Hemmat E El Haddad3, Fatma El-Mougy1
1 Cairo University, Kasr Al Ainy, Faculty of Medicine, Department of Clinical and Chemical Pathology, Cairo, Egypt
2 Shinshu University School of Medicine, Department of Pediatrics, Matsumoto, Nagano, Japan
3 Cairo University, Kasr Al Ainy, Faculty of Medicine, Department of Internal Medicine, Cairo, Egypt

Background: Dysmetabolic iron overload syndrome (DIOS) is characterized by hyperferritinemia and normal transferrin saturation level with components of metabolic syndrome (MS). Among cases of MS, we determined those with DIOS and their characterizations, then we evaluated the association between plasma catecholamines status and hypertension in DIOS.

Methods: We compared 101 hypertensive patients with 50 healthy participants (control group). Iron (iron, transferrin, and ferritin), insulin, and plasma catecholamine (adrenaline, noradrenaline, and dopamine), profiles were measured for both groups. Homeostasis model assessment of insulin resistance index and transferrin saturation were also calculated.

Results: Out of 101 hypertensive patients, 64 were diagnosed with MS, and 6 of the latter met the DIOS diagnostic criteria. Significantly, DIOS patients were older and had lower body mass index (BMI) compared with hypertensive non-DIOS patients with p-values of (0.026), and (0.033), respectively. Adrenaline, noradrenaline, and dopamine levels did not differ significantly between DIOS and non-DIOS patients.

Conclusions: Of the MS patients, 9.3% were diagnosed with DIOS. Accordingly, complete iron profiling should be performed routinely in the cases of MS for early diagnosis of DIOS, to prevent future complications. Further studies are required to test the hypothesis linking older age and lower BMI with the pathogenesis of DIOS.

Keywords: BMI; Catecholamines, DIOS; Hyperferritinemia, Hypertension; Metabolic syndrome
Conflicts of interest:

The authors have no conflict of interests to declare.

Received: June 21, 2022; Revised: November 11, 2022; Accepted: November 16, 2022; Prepublished online: December 2, 2022; Published: December 20, 2022  Show citation

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Hanna HWZ, Baz HN, Al-Kzayer LFY, El Haddad HE, El-Mougy F. Assessment of plasma catecholamines in patients with dysmetabolic iron overload syndrome. J Appl Biomed. 2022;20(4):141-145. doi: 10.32725/jab.2022.016. PubMed PMID: 36708719.
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    References

    1. Adams PC, Barton JC, Guo H, Alter D, Speechley M (2015). Serum ferritin is a biomarker for liver mortality in the Hemochromatosis and Iron Overload Screening Study. Ann Hepatol 14(3): 348-353. Go to original source... Go to PubMed...
    2. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. (2009). Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120(16): 1640-1645. DOI: 10.1161/CIRCULATIONAHA.109.192644. Go to original source... Go to PubMed...
    3. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr., et al. (2003). Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension 42(6): 1206-1252. DOI: 10.1161/01.HYP.0000107251.49515.c2. Go to original source... Go to PubMed...
    4. Dongiovanni P, Fracanzani AL, Fargion S, Valenti L (2011). Iron in fatty liver and in the metabolic syndrome: a promising therapeutic target. J Hepatol 55(4): 920-932. DOI: 10.1016/j.jhep.2011.05.008. Go to original source... Go to PubMed...
    5. Goldstein DS (2010). Catecholamines 101. Clin Auton Res 20(6): 331-352. DOI: 10.1007/s10286-010-0065-7. Go to original source... Go to PubMed...
    6. Grassi G, Seravalle G, Quarti-Trevano F, Dell'Oro R, Bombelli M, Cuspidi C, et al. (2008). Adrenergic, metabolic, and reflex abnormalities in reverse and extreme dipper hypertensives. Hypertension 52(5): 925-931. DOI: 10.1161/HYPERTENSIONAHA.108.116368. Go to original source... Go to PubMed...
    7. Grassi G, Seravalle G, Trevano FQ, Dell'oro R, Bolla G, Cuspidi C, et al. (2007). Neurogenic abnormalities in masked hypertension. Hypertension 50(3): 537-542. DOI: 10.1161/HYPERTENSIONAHA.107.092528. Go to original source... Go to PubMed...
    8. Kew MC (2014). Hepatic iron overload and hepatocellular carcinoma. Liver Cancer 3(1): 31-40. DOI: 10.1159/000343856. Go to original source... Go to PubMed...
    9. Lainé F, Ruivard M, Loustaud-Ratti V, Bonnet F, Calès P, Bardou-Jacquet E, et al. (2017). Metabolic and hepatic effects of bloodletting in dysmetabolic iron overload syndrome: A randomized controlled study in 274 patients. Hepatology 65(2): 465-474. DOI: 10.1002/hep.28856. Go to original source... Go to PubMed...
    10. Mankad AK, Tang DG, Clark WB, Flattery M, Harton S, Katlaps GJ, et al. (2012). Persistent anemia after implantation of the total artificial heart. J Card Fail 18(6): 433-438. DOI: 10.1016/j.cardfail.2012.03.003. Go to original source... Go to PubMed...
    11. Mendler MH, Turlin B, Moirand R, Jouanolle AM, Sapey T, Guyader D, et al. (1999). Insulin resistance-associated hepatic iron overload. Gastroenterology 117(5): 1155-1163. DOI: 10.1016/s0016-5085(99)70401-4. Go to original source... Go to PubMed...
    12. Navar LG (2010). Counterpoint: Activation of the intrarenal renin-angiotensin system is the dominant contributor to systemic hypertension. J Appl Physiol (1985) 109(6): 1998-2000; discussion 2015. DOI: 10.1152/japplphysiol.00182.2010a. Go to original source... Go to PubMed...
    13. Qu HQ, Li Q, Rentfro AR, Fisher-Hoch SP, McCormick JB (2011). The definition of insulin resistance using HOMA-IR for Americans of Mexican descent using machine learning. PLoS One 6(6): e21041. DOI: 10.1371/journal.pone.0021041. Go to original source... Go to PubMed...
    14. Rametta R, Dongiovanni P, Pelusi S, Francione P, Iuculano F, Borroni V, et al. (2016). Hepcidin resistance in dysmetabolic iron overload. Liver Int 36(10): 1540-1548. DOI: 10.1111/liv.13124. Go to original source... Go to PubMed...
    15. Rametta R, Fracanzani AL, Fargion S, Dongiovanni P (2020). Dysmetabolic hyperferritinemia and dysmetabolic iron overload syndrome (DIOS): two related conditions or different entities? Curr Pharm Des 26(10): 1025-1035. DOI: 10.2174/1381612826666200131103018. Go to original source... Go to PubMed...
    16. Ruivard M, Lainé F, Ganz T, Olbina G, Westerman M, Nemeth E, et al. (2009). Iron absorption in dysmetabolic iron overload syndrome is decreased and correlates with increased plasma hepcidin. J Hepatol 50(6): 1219-1225. DOI: 10.1016/j.jhep.2009.01.029. Go to original source... Go to PubMed...
    17. Seravalle G, Trevano FQ, Boggioni I, Buzzi S, Mancia G, Grassi G (2015). Iron overload exerts sympathoexcitatory effects in men with essential hypertension: Microneurographic evidence. J Hypertens 33: e22. DOI: 10.1097/01.hjh.0000467406.56290.0a. Go to original source...

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