Journal of Applied Biomedicine, 2025 (vol. 23), issue 2
Original Research Article
The importance of olfactory and trigeminal event-related potentials (OERPs/TERPs) in the assessment of olfactory function in subjects with chronic rhinosinusitis with nasal polyposis
Karla Janoušková, Oleksii Vorobiov, Kristýna Mamiňák, David Kalfeřt, Libor Vašina, Petra Dytrych, Nikola Pastorková, Jiří Hložek, Daniel Kovář, Jan Vodička, Václav Masopust, Jaromír Astl, Richard Holý
J Appl Biomed 23:57-62, 2025 | DOI: 10.32725/jab.2025.006 
Objectives: Smell impairment (SI) is a well-known symptom of chronic rhinosinusitis with nasal polyps (CRSwNP). The aim of study was to analyze olfactory and trigeminal event-related potentials (OERPs/TERPs) and psychophysical smell tests in subjects with CRSwNP, and its potential role in clinical practice. Methods: Prospective study included 57 subjects. Two investigated groups with CRSwNP and one control group. Group I (n = 20) contained subjects without CRSwNP before septoplasty. Group II (n = 18) contained subjects with CRSwNP without therapy. Group III (n = 19) contained subjects with CRSwNP after intranasal corticosteroid...
Berberine improves atrial remodeling by regulating the AMPK/PPARα signaling pathway in a rabbit model of atrial fibrillation
Yang Wang *, Zhe Sun, Zong-tao Yin, Jian Zhang, Fang-ran Xin, Yin-li Xu, Huai Lan
J Appl Biomed 23:63-79, 2025 | DOI: 10.32725/jab.2025.007
Atrial fibrillation (AF) is a common arrhythmia encountered in clinical practice, characterized by myocardial fibrosis and atrial remodeling as its primary pathological features, and associated with significantly high mortality and disability rates. Currently, there are no specific pharmacological treatments for AF, and traditional anti-arrhythmic drugs have not achieved the desired efficacy, often resulting in a high incidence of adverse drug reactions. Thus, there is an urgent need for the development of novel anti-AF medications. Berberine, the main active component of Coptis chinensis, has been shown to have antiarrhythmic and anti-heart...
Unlocking the secrets of aortic pseudoaneurysms - exploring tensile testing of prostheses, anastomoses, and native vessels in the thoracic aorta: A clinical-engineering correlation
Sandra Rečičárová, Hynek Chlup, Michael Jonák, Ivan Netuka
J Appl Biomed 23:80-90, 2025 | DOI: 10.32725/jab.2025.008
Introduction: This study examines the mechanical properties of thoracic aortic false aneurysms (TAFA) and how the use of vascular prostheses, native vessels, and anastomoses affects their development. This is done through tensile testing, simulating a Bentall procedure, which is the most common surgery leading to TAFA development. Methods: We conducted uniaxial tensile tests on the native right and left coronary arteries from five cadaveric donors. They were anastomosed to two vascular prostheses in the longitudinal and circumferential directions to assess their mechanical responses under load. Results and discussion: All anastomosis specimens ruptured...
Incidence of congenital microcephaly in the Czech Republic: The effect of maternal age
Natálie Friedová, Antonín Šípek, Jan Klaschka, Marek Malý, Pavel Calda, Frantisek Liška, Antonín Šípek, Jr.
J Appl Biomed 23:91-95, 2025 | DOI: 10.32725/jab.2025.009
Objective: Congenital microcephaly is a diverse group of congenital anomalies characterized by a significantly reduced head circumference at birth. The incidence varies widely across regions. This study focuses on the incidence of microcephaly in the Czech Republic. Methods: A retrospective analysis was conducted using data from the National Registry of Congenital Anomalies of the Czech Republic. All cases coded as microcephaly (Q02 code in the 10th revision of the International Classification of Diseases) between 2000 and 2020 were included. Results: A total of 274 cases of congenital microcephaly were identified, with an incidence rate of 1.22 per...