Journal of Applied Biomedicine, 2006 (vol. 4), issue 1
Original Research Article
Influence of Hibiscus sabdariffa (Gongura) on the levels of circulatory lipid peroxidation products and liver marker enzymes in experimental hyperammonemia
Musthafa Mohamed Essa, Perumal Subramanian, Ganapathy Suthakar, Tamilarasan Manivasagam, Kadiyala Babu Dakshayani, Ramar Sivaperumal, Selvaraju Subash, Govindarajaha Vinothini
J Appl Biomed 4:53-58, 2006 | DOI: 10.32725/jab.2006.004 
Hibiscus sabdariffa (Linn) (family Malvaceae), is an annual dicotyledonous herbaceous shrub plant popularly known as 'Gongura' in Hindi or 'Pulicha keerai' in Tamil, which is an indigenous edible medicinal plant used in Ayurvedic Medicine in India, China and Thailand. We have investigated the influence of Hibiscus sabdariffa leaf extract (HSEt) on the levels of circulatory ammonia, urea, lipid peroxidation products such as TBARS (thiobarbituric acid and reactive substances), HP (hydroperoxides) and liver marker enzymes such as AST (aspartate transaminase), ALT (alanine transaminase) and ALP (alkaline phosphatase), for its hepatoprotective...
Reviews
Chronobiology's progress. Part I, season's appreciations 2004-2005: time-, frequency-, phase-, variable-, individual-, age- and site-specific chronomics
Franz Halberg, Germaine Cornélissen, George Katinas, Levan Tvildiani, Marina Gigolashvili, Ketevan Janashia, Tim Toba, Miguel Revilla, Philip Regal, Robert B. Sothern, Hans W. Wendt, Zhengrong Wang, Michal Zeman, Rita Jozsa, R.B. Singh, Gen Mitsutake, Sergei M. Chibisov, Jong Lee, Dan Holley, James E. Holte, Robert P. Sonkowsky, Othild Schwartzkopff, Patrick Delmore, Kuniaki Otsuka, Earl E. Bakken, Jerzy Czaplicki, the International BIOCOS Group
J Appl Biomed 4:1-38, 2006 | DOI: 10.32725/jab.2006.001
New components of transdisciplinary spectra or known components in new variables in us, matching those around us, are being mapped. Their hardly trivial interactions associated with the good and bad around us - from religiosity to crime and war - are being rendered measurable, for the eventual development of countermeasures to the diseases of societies and nations. Internal cycles not only underlie life itself and underlie our evolving genetics at all levels of organization; they also constitute the essential control and reference information in all transdisciplinary science. In preparing for travel to Mars and other missions in space that may take...
From oxidative DNA damage to molecular epidemiology
Katarína Volkovová, Mária Dušinská, Andrew R. Collins
J Appl Biomed 4:39-43, 2006 | DOI: 10.32725/jab.2006.002
Reactive forms of oxygen are released during normal respiration, by the oxidative burst of the macrophages in response to infection, and by a variety of exogenous environmental agents. Oxidative stress, caused by imbalance between the production of reactive forms of oxygen and their elimination, leads to oxidative damage of biomolecules. It is generally accepted that oxidative stress is involved either as cause or effect in a variety of human degenerative diseases. The antioxidant hypothesis proposes that natural antioxidants in fruit and vegetables scavenge free radicals before they can cause damage. To test the hypothesis a reliable biomarker for...
Calreticulin and cellular adhesion/migration-specific signalling pathways
Eva Szabo, Sylvia Papp, Michal Opas
J Appl Biomed 4:45-52, 2006 | DOI: 10.32725/jab.2006.003
Calreticulin is a Ca2+-binding protein of the ER/SR, from where it acts as a chaperone, and affects calcium homeostasis, gene expression and cell adhesion. Cell adhesion to the extracellular matrix can generate transmembrane signals important for cell survival and migration. In a variety of cell types, integrin stimulation by ECM proteins, such as fibronectin, leads to changes in intracellular protein tyrosine phosphorylation. Tyrosine phosphorylation leads to the co-localization of focal adhesion kinase, vinculin and paxillin at focal contacts. Interaction between focal adhesion kinase and paxillin is critical for the activation of signaling...