Journal of Applied Biomedicine, 2022 (vol. 20), issue 2
Rare case of alimentary butylbiphenyl intoxication
Damián Šimčík, Viktor Voříšek, Martin Jakl
J Appl Biomed 20:80-82, 2022 | DOI: 10.32725/jab.2022.007 
Background: Unexpected accidental intoxication by uncommon industrial substances is a rare, but challenging and perilous event. To our best knowledge, this is the first reported case of 3,4',5,6'-tetra-tert-butylbiphenyl-2,3'-diol intoxication. Case report: A 20-year-old man was referred to the Department of Emergency Medicine after seven days of nausea and vomiting triggered by drinking mead. Very high doses of 3,4',5,6'-tetra-tert-butylbiphenyl-2,3'-diol were detected in mead, blood, and urine samples. To prove the intoxication, gas chromatography - ion trap was performed. Symptoms of intoxication persisted for two weeks without significant organ...
Original Research Article
Exploring the therapeutic potential of acetonic plant extracts in the healing of skin wounds infected with multidrug resistant pathogens
Maha A. Khalil, Eman H.F. Abd El-Zaher, Olaa Abd El-Salam, Sameh S. Ali
J Appl Biomed 20:45-55, 2022 | DOI: 10.32725/jab.2022.006
Open wounds are easily susceptible to infection by multi-drug resistant (MDR) pathogens. The emergence of MDR super bacteria such as Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus spp, fungi such as Aspergillus niger and Candida spp, has been identified to significantly increase the incidence rate. Therefore, it is necessary to develop a suitable barrier to prevent infection and enhance wound healing. On the other hand, medicinal plants could represent a significant source of new antimicrobial drugs for combating MDR pathogens. Out of 60 clinical skin burn cases, 51 patients (85%) had polymicrobial infections, while...
Kilohertz alternating current neuromodulation of the pudendal nerves: effects on the anal canal and anal sphincter in rats
Rosa L. Coolen, Koen M. Emmer, Panagiota I. Spantidea, Els van Asselt, Jeroen R. Scheepe, Wouter A. Serdijn, Bertil F. M. Blok
J Appl Biomed 20:56-69, 2022 | DOI: 10.32725/jab.2022.009
The first two objectives were to establish which stimulation parameters of kilohertz frequency alternating current (KHFAC) neuromodulation influence the effectiveness of pudendal nerve block and its safety. The third aim was to determine whether KHFAC neuromodulation of the pudendal nerve can relax the pelvic musculature, including the anal sphincter. Simulation experiments were conducted to establish which parameters can be adjusted to improve the effectiveness and safety of the nerve block. The outcome measures were block threshold (measure of effectiveness) and block threshold charge per phase (measure of safety). In vivo, the pudendal nerves...
Heart rate dynamics in the prediction of coronary artery disease and myocardial infarction using artificial neural network and support vector machine
Rahul Kumar, Yogender Aggarwal *, Vinod Kumar Nigam
J Appl Biomed 20:70-79, 2022 | DOI: 10.32725/jab.2022.008
Background: Atherosclerosis leads to coronary artery disease (CAD) and myocardial infarction (MI), a major cause of morbidity and mortality worldwide. The computer-aided prognosis of atherosclerotic events with the electrocardiogram (ECG) derived heart rate variability (HRV) can be a robust method in the prognosis of atherosclerosis events. Methods: A total of 70 male subjects aged 55 ± 5 years participated in the study. The lead-II ECG was recorded and sampled at 200 Hz. The tachogram was obtained from the ECG signal and used to extract twenty-five HRV features. The one-way Analysis of variance (ANOVA) test was performed to find the significant...